ArticleBMC systems biology2019
Mathematical modeling of movement on fitness landscapes.
Article in BMC systems biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMovement of populations on fitness landscapes has been a problem of interest for a long time. While the subject has been extensively developed theoretically, reconciliation of the theoretical work with recent experimental data has not yet happened. In this work, we develop a computational framework and study evolution of the simplest transcription network between a single regulator, R and a single target protein, T.
resultsThrough our simulations, we track evolution of this transcription network and comment on its dynamics and statistics of this movement. Significantly, we report that there exists a critical parameter which controls the ability of a network to reach the global fitness peak on the landscape. This parameter is the fraction of all permissible values of a biochemical parameter that can be accessed from its current value via a single mutation.
conclusionsOverall, through this work, we aim to present a general framework for analysis of movement of populations (and particularly regulatory networks) on landscapes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.