Evidence map›Paper›PMID 30818999›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2019

Different morphological and gene expression profile in placentas of the same sickle cell anemia patient in pregnancies of opposite outcomes.

Letícia C Baptista, Camilla O Figueira, Bruno B Souza, Kleber Y Fertrin, Arthur Antolini, Fernando F Costa, Mônica B de Melo, Maria Laura Costa

Abstract readCase Reports
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In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Letícia C Baptista1 Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas - UNICAMP, Campinas, SP 13083-875, Brazil.
Camilla O Figueira2 Department of Obstetrics and Gynecology, University of Campinas - UNICAMP, Campinas, SP 13083-880, Brazil.
Bruno B Souza1 Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas - UNICAMP, Campinas, SP 13083-875, Brazil.
Kleber Y Fertrin3 Division of Hematology, University of Washington, Seattle, WA 98195-7230, USA.
Arthur Antolini4 Department of Pathology, University of Campinas - UNICAMP, Campinas, SP 13083-887, Brazil.
Fernando F Costa5 Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, SP 13083-878.
Mônica B de Melo1 Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas - UNICAMP, Campinas, SP 13083-875, Brazil.
Maria Laura Costa2 Department of Obstetrics and Gynecology, University of Campinas - UNICAMP, Campinas, SP 13083-880, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementEnvironmentally induced changes in placental morphological and molecular phenotypes may provide relevant insight towards pathophysiology of diseases. The rare opportunity to evaluate the same patient, with sickle cell anemia (SCA), in two different pregnancies, of opposite outcomes (one early onset severe preeclampsia (PE) and the other mostly non-complicated) can prove such concept. In addition, the comparison to other conditions of known placental and vascular/inflammatory involvement strengthens such findings. Our results suggest that the clinical association between SCA and PE can be supported by common pathophysiological mechanisms, but that pathways involving response to copper and triglyceride metabolism may be important drivers of the pathophysiology of PE. Future studies using in a larger number of samples should confirm these findings and explore pathways involved in the pathophysiology of PE and its relationship with SCA.

Indexed as

Anemia, Sickle CellPlacentaPregnancy Complications, HematologicPregnancy OutcomeTranscriptomeFemaleFetal Growth RetardationHumansPregnancyYoung Adultand pregnancygene expressionPlacentapreeclampsiasickle cell disease

Identifiers

PMID30818999
PMCPMC6488870

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.