Caution Against Overinterpreting Opiate Receptor Stimulation as Mediating Antidepressant Effects of Ketamine.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed.

1. Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials.The international journal of neuropsychopharmacology · 2020
   Trial
2. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
   Trial
3. Opioid Receptor μ-1 and Ketamine Effects in a Suicidal Depression Trial: A Post Hoc Exploration.Journal of clinical psychopharmacology
   Trial
4. Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024
   Review
5. Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine.Neuropharmacology · 2023
   Review
6. Mechanisms of ketamine and its metabolites as antidepressants.Biochemical pharmacology · 2022
   Review
7. Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat.Frontiers in psychiatry · 2022
   Article
8. Ketamine: A tale of two enantiomers.Journal of psychopharmacology (Oxford, England) · 2021
   Review
9. "Novel Psychopharmacology for Depressive Disorders".Advances in experimental medicine and biology · 2021
   Review
10. [The next psychoactive drugs: From imipramine to ketamine].Bulletin de l'Academie nationale de medecine · 2020
    Review
11. The next psychoactive drugs: From imipramine to ketamine.Bulletin de l'Academie nationale de medecine · 2020
    Review
12. Ketamine: The final frontier or another depressing end?Behavioural brain research · 2020
    Review
13. Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
14. Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function.Molecular psychiatry · 2019
    Review
15. Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.Psychiatry and clinical neurosciences · 2019
    Review

Corrections and comments

• Commented on by
  Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora.2019
• Comment on
  Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.2018

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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