Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism: Is It a Ketamine-Specific Effect?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Structural basis of opioid receptor activation by PCP and ketamine.Nature structural & molecular biology · 2026
   Article
2. Mechanism of antidepressant action of ketamine and differences between its two enantiomers.Journal of anesthesia and translational medicine · 2025
   Review
3. Mechanisms of ketamine and its metabolites as antidepressants.Biochemical pharmacology · 2022
   Review
4. Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat.Frontiers in psychiatry · 2022
   Article
5. Retracing our steps to understand ketamine in depression: A focused review of hypothesized mechanisms of action.The mental health clinician · 2021
   Review
6. Ketamine: A tale of two enantiomers.Journal of psychopharmacology (Oxford, England) · 2021
   Review
7. Modulation of amygdala reactivity following rapidly acting interventions for major depression.Human brain mapping · 2020
   Article
8. Single and repeated ketamine treatment induces perfusion changes in sensory and limbic networks in major depressive disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020
   Article
9. Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.Psychiatry and clinical neurosciences · 2019
   Review

Corrections and comments

• Commented on by
  Target Population, Dose, and Timing Considerations for Understanding Naltrexone's Subjective Effect: Response to Amiaz.2019
• Comment on
  Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.2018

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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