Evidence map›Paper›PMID 30818985›Full record

ReviewThe American journal of psychiatry2019

Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.

Heidi C Meyer, Francis S Lee

Open access · bronzeAbstract readReview
In one paragraph

Review in The American journal of psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
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  13. Oligodendrocytes matter: a review of animal studies on early adversity.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  14. Article
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  19. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Heidi C MeyerThe Department of Psychiatry and the Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York.
Francis S LeeThe Department of Psychiatry and the Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York.
Cornell University · US

Funding

J. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8M
The Impact of the BDNF Val66Met Prodomain on Cognitive Function in a Mouse Model of Alzheimer's DiseaseR01NS052819 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMPSTEAD, BARBARA L, LEE, FRANCIS SANG YONG · 2005 to 2019
$5.3M
NCATS NIH HHS TL1 TR002386NINDS NIH HHS R01 NS052819
6 · The paper itself

Abstract

The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened focus on both typical and atypical trajectories of neural circuit maturation. Mounting evidence has highlighted the immense neural plasticity apparent in the developing brain. Although in many cases adaptive, the capacity for neural circuit alteration also induces a state of vulnerability to environmental perturbations, such that early-life experiences have long-lasting implications for cognitive and emotional functioning in adulthood. The authors outline preclinical and neuroimaging studies of normative human brain circuit development, as well as parallel efforts covered in this issue of the Journal, to identify brain circuit alterations in psychiatric disorders that frequently emerge in developing populations. Continued translational research into the interactive effects of neurobiological development and external factors will be crucial for identifying early-life risk factors that may contribute to the emergence of psychiatric illness and provide the key to optimizing treatments.

Indexed as

AdolescentAdolescent DevelopmentBrainChildChild DevelopmentHumansMental DisordersNeurodevelopmental DisordersPsychopathologyRisk FactorsStress, PsychologicalAdolescentsAnxiety Disorder-GeneralizedBiological MarkersNeurodevelopmentNeuroimagingSchizophrenia

Identifiers

PMID30818985
PMCPMC11019454
OpenAlexW2918572441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.