Evidence map›Paper›PMID 30818883›Full record

ArticleMolecules (Basel, Switzerland)2019

Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors.

Ke Huang, Lulu Jiang, Huiti Li, Deyong Ye, Lu Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ke HuangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China. kehuang13@fudan.edu.cn.
Lulu JiangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China. 18111030012@fudan.edu.cn.
Huiti LiDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China. 17211030005@fudan.edu.cn.
Deyong YeDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China. dyye@shmu.edu.cn.
Lu ZhouDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China. zhoulu@fudan.edu.cn.

Funding

Chinese National Natural Science Foundation 21472026, 21877014Shanghai Municipal Committee of Science and Technology 14XD1400300the program for Shanghai Rising Star 15QA1400300
6 · The paper itself

Abstract

Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis and biosynthesis to promote cancer cell proliferation, and is believed to be a promising target for cancer therapy. Herein, based on the anthraquinone scaffold, we synthesized 31 anthraquinone derivatives and investigated the structure-activity relationship (SAR). The 3-substitient of sulfonamide on the anthraquinone scaffold was essential for maintaining potency and the modifications of the hydroxyl of alizarin would cause a sharp decrease in potency. In the meantime, we determined the co-crystal structure of PGAM1 and one of the anthraquinone inhibitors

Indexed as

Cell ProliferationAnthraquinonesAntineoplastic AgentsCrystallizationEnzyme InhibitorsHumansLung NeoplasmsMolecular StructurePhosphoglycerate MutaseStructure-Activity RelationshipSulfonamidesTumor Cells, CulturedAnthraquinonesAntineoplastic AgentsEnzyme InhibitorsPhosphoglycerate Mutasephosphoglycerate mutase 1, humanSulfonamidesanthraquinone inhibitorscancer treatmentco-crystal structurephosphoglycerate mutase 1

Identifiers

PMID30818883
PMCPMC6429356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.