ArticleNutrients2019
Variability of Serum Proteins in Chinese and Dutch Human Milk during Lactation.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Antimicrobial Activity of Milk Whey in Different Mammals.Bulletin of experimental biology and medicine · 2023Article
- Comparative Proteomic Analysis of Proteins in Breast Milk during Different Lactation Periods.Nutrients · 2022Article
- Plasma Protein Profile of Lactating Women from Two Primary Health Centers in Jakarta, Indonesia.Reports of biochemistry & molecular biology · 2022Article
- Exploring Human Milk Dynamics: Interindividual Variation in Milk Proteome, Peptidome, and Metabolome.Journal of proteome research · 2022Article
- Proteoform Profiles Reveal That Alpha-1-Antitrypsin in Human Serum and Milk Is Derived From a Common Source.Frontiers in molecular biosciences · 2022Article
- Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity.International journal of molecular sciences · 2021Article
- Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study.Frontiers in nutrition · 2021Article
- Longitudinal changes in the bioactive proteins in human milk of the Chinese population: A systematic review.Food science & nutrition · 2021Review
- Serum Protein N-Glycans in Colostrum and Mature Milk of Chinese Mothers.Journal of agricultural and food chemistry · 2020Article
- Quantitative Longitudinal Inventory of theJournal of proteome research · 2020Article
- Human Milk and Lactation.Nutrients · 2020Article
- Degradation of Proteins From Colostrum and Mature Milk From Chinese Mothers Using anFrontiers in nutrition · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To better understand the variability of the type and level of serum proteins in human milk, the milk serum proteome of Chinese mothers during lactation was investigated using proteomic techniques and compared to the milk serum proteome of Dutch mothers. This showed that total milk serum protein concentrations in Chinese human milk decreased over a 20-week lactation period, although with variation between mothers in the rate of decrease. Variation was also found in the composition of serum proteins in both colostrum and mature milk, although immune-active proteins, enzymes, and transport proteins were the most abundant for all mothers. These three protein groups account for many of the 15 most abundant proteins, with these 15 proteins covering more than 95% of the total protein concentrations, in both the Chinese and Dutch milk serum proteome. The Dutch and Chinese milk serum proteome were also compared based on 166 common milk serum proteins, which showed that 22% of the 166 serum proteins differed in level. These differences were observed mainly in colostrum and concern several highly abundant proteins. This study also showed that protease inhibitors, which are highly correlated to immune-active proteins, are present in variable amounts in human milk and could be relevant during digestion.
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