Evidence map›Paper›PMID 30818269›Full record

ArticleNeuroImage. Clinical2019

Structural brain correlates of fatigue in older adults with and without Parkinson's disease.

Benzi M Kluger, Qing Zhao, Jared J Tanner, Nadine A Schwab, Shellie-Anne Levy, Sarah E Burke, Haiqing Huang, Mingzhou Ding, Catherine Price

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Research progress of chronic fatigue in neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. White matter changes in Parkinson's disease.NPJ Parkinson's disease · 2023
    Review
  8. A Multi-Dimensional Model of Fatigue in Old Age: Implications for Brain Aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
  9. Article
  10. Review
  11. The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022
    Article
  12. Article
  13. Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  14. Article
  15. Extra-motor manifestations in post-polio syndrome (PPS): fatigue, cognitive symptoms and radiological features.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Neural and dopaminergic correlates of fatigue in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Benzi M KlugerNeurology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: benzi.kluger@ucdenver.edu.
Qing ZhaoJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Jared J TannerClinical and Health Psychology, Center for Movement Disorders and Neurorestoration, Anesthesiology, University of Florida, Gainesville, FL, USA.
Nadine A SchwabClinical and Health Psychology, Center for Movement Disorders and Neurorestoration, Anesthesiology, University of Florida, Gainesville, FL, USA.
Shellie-Anne LevyClinical and Health Psychology, Center for Movement Disorders and Neurorestoration, Anesthesiology, University of Florida, Gainesville, FL, USA.
Sarah E BurkeJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Haiqing HuangJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Mingzhou DingJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Catherine PriceClinical and Health Psychology, Center for Movement Disorders and Neurorestoration, Anesthesiology, University of Florida, Gainesville, FL, USA. Electronic address: cep23@phhp.ufl.edu.
University of Florida · USUniversity of Colorado Denver · USUniversity of Florida Health · US

Funding

UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
Intrinsic Cortical Networks and Cognitive Dysfunction in Parkinson???s DiseaseK02NS080885 · NINDS · UNIVERSITY OF COLORADO DENVER · PI KLUGER, BENZI M · 2013 to 2017
$824k
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
Measuring Cognitive Fatigability in Older AdultsR21AG044862 · NIA · UNIVERSITY OF FLORIDA · PI DING, MINGZHOU, KLUGER, BENZI M · 2014 to 2015
$409k
NCATS NIH HHS UL1 TR000064NIA NIH HHS R21 AG044862NINDS NIH HHS K02 NS080885NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386
6 · The paper itself

Abstract

Fatigue is one of the most common and disabling nonmotor symptoms seen in Parkinson's disease (PD) and is also commonly seen in healthy older adults. Our understanding of the etiology of fatigue in older adults with or without PD is limited and it remains unclear whether fatigue in PD is specifically related to PD pathology. The objective of this study was thus to determine whether fatigue in PD was associated with structural changes in gray or white matter and explore whether these changes were similar in older adults without PD. Magnetic resonance imaging (T

Indexed as

Magnetic Resonance ImagingAgedBrainFatigueFemaleHumansMaleMiddle AgedParkinson DiseaseArousalNeuroanatomyNeuropsychiatry: ImagingParkinson's diseaseParkinson's disease imaging

Identifiers

PMID30818269
PMCPMC6396012
OpenAlexW2916873743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.