Evidence map›Paper›PMID 30818064›Full record

ArticleNeurobiology of disease2019

Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease.

Kelly S Kirkley, Katriana A Popichak, Sean L Hammond, Cecilia Davies, Lindsay Hunt, Ronald B Tjalkens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kelly S KirkleyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Katriana A PopichakDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Sean L HammondDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Cecilia DaviesDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Lindsay HuntDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Ronald B TjalkensDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523; Program in Molecular, Cellular and Integrative Neuroscience, Colorado State University, Fort Collins, CO, USA 80523. Electronic address: Ron.Tjalkens@colostate.edu.
Colorado State University · US

Funding

Neuroinflammation and developmental vulnerability to manganese toxicityR01ES021656 · NIEHS · COLORADO STATE UNIVERSITY · PI TJALKENS, RONALD · 2013 to 2022
$4.2M
Alphavirus-manganese interactions and dopaminergic neurodegenerationR21ES024183 · NIEHS · COLORADO STATE UNIVERSITY · PI TJALKENS, RONALD · 2014 to 2015
$427k
NIEHS NIH HHS R01 ES021656NIEHS NIH HHS R21 ES024183
6 · The paper itself

Abstract

Neuroinflammatory activation of glia is considered a pathological hallmark of Parkinson's disease (PD) and is seen in both human PD patients and in animal models of PD; however, the relative contributions of these cell types, especially astrocytes, to the progression of disease is not fully understood. The transcription factor, nuclear factor kappa B (NFκB), is an important regulator of inflammatory gene expression in glia and is activated by multiple cellular stress signals through the kinase complex, IKK2. We sought to determine the role of NFκB in modulating inflammatory activation of astrocytes in a model of PD by generating a conditional knockout mouse (hGfapcre/Ikbk2

Indexed as

AnimalsAstrocytesCell DeathDopaminergic NeuronsI-kappa B KinaseMaleMiceMice, KnockoutMPTP PoisoningNF-kappa BProbenecidSubstantia NigraI-kappa B KinaseIkbkb protein, mouseNF-kappa BProbenecidAstrocytesIKK2MPTPNeuroinflammationNFκBTransgenic models

Identifiers

PMID30818064
PMCPMC6588478
OpenAlexW2918112026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.