SynthesisNeuroscience and biobehavioral reviews2019
The genetic underpinnings of callous-unemotional traits: A systematic research review.
Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Parenting Characteristics and Callous-Unemotional Traits in Children Aged 0-6 Years: A Systematic Narrative Review.Child psychiatry and human development · 2025Pooled it
- Treatment of childhood disruptive behavior disorders and callous-unemotional traits: a systematic review and two multilevel meta-analyses.Journal of child psychology and psychiatry, and allied disciplines · 2023Pooled it
- Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Why Students Higher in Callous-Unemotional Traits Are More Resistant to Targeted Anti-Bullying Interventions by Teachers: The Role of Biased Perceptions.Research on child and adolescent psychopathology · 2026Trial
- Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth.bioRxiv : the preprint server for biology · 2026Article
- The nature and nurture of primary and secondary callous-unemotional traits: evidence from two independent twin samples.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Using Machine Learning to Identify Infant and Child Environmental and Biological Predictors of Callous-Unemotional Traits.Research on child and adolescent psychopathology · 2026Article
- Infectious diseases and childhood disruptive behavior disorders: a reappraisal.Frontiers in cellular and infection microbiology · 2026Article
- Maternal psychopathic traits prospectively predict youth callous-unemotional traits.Frontiers in child and adolescent psychiatry · 2026Article
- Understanding the Etiology of Externalizing Problems in Young Children: The Roles of Callous-Unemotional Traits and Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Genetic and Environmental Influences on the Development of Callous-Unemotional Behaviors in the Preschool Period.Research on child and adolescent psychopathology · 2025Article
- Long-term stability of self-reported psychopathic traits in former at-risk adolescents in youth welfare and juvenile justice institutions.Child and adolescent psychiatry and mental health · 2025Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Exploring the Unique and Interactive Effects Between Callous-Unemotional and Autistic Traits with Parental Practices, Care, and Distress in a Community Sample.Research on child and adolescent psychopathology · 2024Article
- Objective Linguistic Markers Associated with Callous-Unemotional Traits in Early Childhood.Research on child and adolescent psychopathology · 2024Article
- Unique versus shared neural correlates of externalizing psychopathology in late childhood.Journal of psychopathology and clinical science · 2024Article
- Callousness, exploitativeness, and tracking of cooperation incentives in the human default network.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Independent Contributions of Callous-Unemotional Behaviors and Quantitative Autistic Traits to Aggression in Early Childhood.JAACAP open · 2024Article
- Measurement invariance of the inventory of Callous‑Unemotional traits in different age groups from preschool age to late adolescence in Germany.BMC psychology · 2024Article
- Primary and Secondary Variants of Callous-Unemotional Traits in Community Youths: Differences in Anticipatory Fear.Children (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundCallous-unemotional (CU) traits represent the affective features of psychopathy used to delineate youth at high risk for externalizing pathology. The genetic etiology CU traits is not currently well-understood.
methodsThe current review surveyed the literature for studies on the genetic underpinnings of CU traits and integrated information from 39 genetic studies.
resultsThe results from 24 studies with quantitative data suggest that the heritability for CU traits is likely between 36-67%. A majority of the 16 molecular genetic studies focused on candidate genes in the serotonin and oxytocin systems with results that have not been well replicated. Although two genome-wide association studies have been conducted, no genome-wide significant loci have been discovered. DISCUSSION: There is some evidence to suggest that the serotonin and oxytocin systems may play a role in CU traits; however, there is currently not enough evidence to implicate specific genetic mechanisms. The authors encourage researchers to continue to apply the most up-to-date and relevant methodology, specifically collaborations and consortiums using genome-wide and polygenic methods.
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Registered trials
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