ArticlePloS one2019
Strong association between vibration perception thresholds at low frequencies (4 and 8 Hz), neuropathic symptoms and diabetic foot ulcers.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- How to determine hands' vibration perception thresholds - a systematic review.Behavior research methods · 2024Pooled it
- Can diabetic peripheral neuropathy influence the final outcome of physical performance after a combined training program in older adults? A double-blind quasi-experimental study.Physiological reports · 2026Article
- Smartphone-based App to Assess Diabetic Peripheral Neuropathy.medRxiv : the preprint server for health sciences · 2026Article
- Vibration perception threshold assessments: Comparing the Staircase and von Békésy methods.Attention, perception & psychophysics · 2026Article
- Pain alleviation in diabetic neuropathy using hybrid closed loop insulin pumps (PAINLESS) - A randomised crossover trial protocol.PloS one · 2026Article
- Neurofeedback Training for Managing Neuropathic Pain-Like Features in Chronic Musculoskeletal Pain: Protocol for an Open-Label Pilot Feasibility Clinical Trial.JMIR research protocols · 2025Article
- Method for Assessing Numbness and Discomfort in Cyclists' Hands.Sensors (Basel, Switzerland) · 2025Article
- The diagnostic test performance of clinical point-of-care testing in relation to quantitative sensory testing for neurosensory injury among workers exposed to hand-arm vibration.Journal of occupational health · 2025Article
- Curcumin Promotes Diabetic Foot Ulcer Wound Healing by Inhibiting miR-152-3p and Activating the FBN1/TGF-β Pathway.Molecular biotechnology · 2024Article
- Article
- Potential predictive effect of mechanical properties of the plantar skin and superficial soft tissue, and vibration perception on plantar loading during gait in individuals with diabetes.BMC musculoskeletal disorders · 2023Article
- Article
- The Effect of Subliminal Electrical Noise Stimulation on Plantar Vibration Sensitivity in Persons with Diabetes Mellitus.Biomedicines · 2022Article
- Addressing Chemotherapy-Induced Peripheral Neuropathy Using Multi-Frequency Vibrometry and Patient-Reported Outcomes.Journal of clinical medicine · 2022Article
- Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging.Journal of diabetes and its complications · 2022Article
- Sensory Dysfunction in Old Age.Deutsches Arzteblatt international · 2021Article
- Low and High Frequency Vibration Perception Thresholds Can Improve the Diagnosis of Diabetic Neuropathy.Journal of clinical medicine · 2021Article
- Vibrotactile sense 5 years after carpal tunnel release in people with diabetes: A prospective study with matched controls.Diabetic medicine : a journal of the British Diabetic Association · 2021Observational
- The Mechanoreceptor's Role in Plantar Skin Changes in Individuals with Diabetes Mellitus.Journal of clinical medicine · 2021Article
- Normative values of the vibration perception thresholds at finger pulps and metatarsal heads in healthy adults.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate whether multi-frequency measurement of vibration perception thresholds (VPTs) can identify individuals with a high risk of developing diabetic foot ulcer or neuropathic symptoms.
methodsVPTs were measured at six different frequencies (4, 8, 16, 32, 64 and 125 Hz) on metatarsal heads 1 and 5 on the sole of the foot using a standard VibroSense Meter device in 535 type 1 diabetic (T1DM) patients and 717 non-diabetic control subjects. VPTs in control subjects were used to establish normal values for five different age groups for male and female subjects respectively. Normal values were defined as a VPT below the mean plus 1.66 x standard deviation for each group. Various definitions of abnormal VPTs were tested using either all frequencies, only lowest VPT frequencies (4 and 8 Hz) or only highest VPT frequencies (64 and 125 Hz).
resultsThe VPTs were higher in T1DM patients than in non-diabetic control subjects matched for age and gender. The low frequencies, 4 and 8 Hz, particularly were associated with the risk of diabetic foot ulcer (OR 40.7 [5.4-308.4], p = 0.0003) and with difficulties in balance and or gait (OR 1.89 [1.04-3.46], p = 0.04) difficulties and weakness (OR 2.77 [1.25-6.16], p = 0.01). The VPTs at the 125 Hz frequency were higher in short duration (≤ 10 yrs.) T1DM patients compared to age- and gender-matched control subjects.
conclusionsVibration perception thresholds at low frequencies seem to be a better indicator of the risk of developing diabetic foot ulcers, gait or balance problems or weakness of the foot. The 125 Hz frequency, however, seemed to be impaired earlier and it was the only pathological VPT frequency in patients with short duration of diabetes.This study suggests that at least four different frequencies (4, 8, 64 and 125 Hz) should be included in any examination in order to obtain a complete evaluation of the risk factors for diabetic neuropathy and diabetic foot ulcers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.