Evidence map›Paper›PMID 30817778›Full record

Trial reportPloS one2019

P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study.

Marie B Nielsen, Nicoline V Krogstrup, Gertrude J Nieuwenhuijs-Moeke, Mihai Oltean, Frank J M F Dor, Bente Jespersen, Henrik Birn

Erratum issued Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01395719 (Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01395719 naunknown statusnot on this map

Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function

TypeinterventionalSponsorUniversity of AarhusRan2011 to 2016Enrolled220ConditionsKidney Transplantation, Delayed Graft Function, Acute Kidney Injury, Glomerular Filtration RateArmsRemote ischemic conditioning
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Role of novel biomarkers in kidney transplantation.World journal of transplantation · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Marie B NielsenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3587-6638
Nicoline V KrogstrupDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Gertrude J Nieuwenhuijs-MoekeDepartment of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-9874-2632
Mihai OlteanThe Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
Frank J M F DorDivision of HPB & Transplant Surgery, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Bente JespersenDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Henrik BirnDepartment of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Aarhus University · DKAarhus University Hospital · DKHammersmith Hospital · GBSahlgrenska University Hospital · SEUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.

methods225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).

resultsAll biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early biomarker levels and mGFR or eGFR at three or twelve months.

conclusionHigh plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.

trial registrationClinicalTrials.gov NCT01395719.

Indexed as

AgedAllograftsBiomarkersCreatinineDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHumansKidneyKidney Failure, ChronicKidney TransplantationLipocalin-2MaleMiddle AgedPredictive Value of TestsBiomarkersCreatinineLCN2 protein, humanLipocalin-2

Identifiers

PMID30817778
PMCPMC6394926
OpenAlexW2920667541

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.