Trial reportPloS one2019
Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Patterned Oral Somatosensory Entrainment
Maternal Role in Sensory-motor Stimulation for Oral Feed Establishment in Preterm Neonates: MSMS Trial
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Eligible Infants Included in Neonatal Clinical Trials and Reasons for Noninclusion: A Systematic Review.JAMA network open · 2024Pooled it
- Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials: A Systematic Review.JAMA network open · 2023Pooled it
- [Effect of oral motor intervention in improving brain function development in preterm infants: a randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- A Low-Cost Device for Measuring Non-Nutritive Sucking in Newborns.Sensors (Basel, Switzerland) · 2025Article
- The budget impact of patterned frequency-modulated oral stimulation to promote non-nutritive sucking in preterm infants in the United States.Frontiers in pediatrics · 2025Article
- The effectiveness of oral motor interventions on the weight gain, independent oral feeding, and length of hospital stay in hospitalized preterm infants: A systematic review and meta-analysis.Health science reports · 2024Article
- Non-Nutritive Suck Parameters Measurements Using a Custom Pressure Transducer System.Journal of visualized experiments : JoVE · 2024Article
- Nipple properties affect sensorimotor integration during bottle feeding in an infant pig model.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2023Review
- The Importance of Rhythmic Stimulation for Preterm Infants in the NICU.Children (Basel, Switzerland) · 2021Review
- Sucking versus swallowing coordination, integration, and performance in preterm and term infants.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Management of Oral Feeding Challenges in Neonatal Intensive Care Units (NICUs): A National Survey in China.Frontiers in pediatrics · 2020Article
- Abnormal Nutritive Sucking as an Indicator of Neonatal Brain Injury.Frontiers in pediatrics · 2020Review
- Automatic Nonnutritive Suck Waveform Discrimination and Feature Extraction in Preterm Infants.Computational and mathematical methods in medicine · 2019Article
- Preterm Neurodevelopmental Outcomes Following Orosensory Entrainment Intervention.Journal of neonatal nursing : JNN · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of patterned, frequency-modulated oro-somatosensory stimulation on time to full oral feeds in preterm infants born 26-30 weeks gestation. STUDY
designThis is a multicenter randomized controlled trial. The experimental group (n = 109) received patterned, frequency-modulated oral stimulation via the NTrainer system through a pulsatile pacifier and the control group (n = 101) received a non-pulsatile pacifier. Intent-to-treat analysis (n = 210) was performed to compare the experimental and control groups and the outcomes were analyzed using generalized estimating equations. Time-to-event analyses for time to reach full oral feeds and length of hospital stay were conducted using Cox proportional hazards models.
resultsThe experimental group had reduction in time to full oral feeds compared to the control group (-4.1 days, HR 1.37 (1.03, 1.82) p = 0.03). In the 29-30 weeks subgroup, infants in the experimental group had a significant reduction in time to discharge (-10 days, HR 1.87 (1.23, 2.84) p < 0.01). This difference was not observed in the 26-28 weeks subgroup. There was no difference in growth, mortality or morbidities between the two groups.
conclusionsPatterned, frequency-modulated oro-somatosensory stimulation improves feeding development in premature infants and reduces their length of hospitalization.
trial registrationClinicalTrials.gov NCT01158391.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.