SynthesisMedicine2019
Association of loss of muscle mass with mortality in liver cirrhosis without or before liver transplantation: A systematic review and meta-analysis.
Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Effect of sarcopenia on the survival of patients undergoing liver transplantation: a meta-analysis.Surgery today · 2025Pooled it
- Opportunistic computed tomography-based sarcopenia screening and mortality after liver transplantation: a systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2025Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Impact of Muscle Mass on the Performance of Creatinine-Based eGFR Equations and Mortality Risk Assessment After Kidney Transplantation.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sina Score as a New Machine Learning-Derived Online Prediction Model of Mortality for Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Evolution in peak oxygen uptake and its impact on physical activities of daily living in chronic kidney disease and transplantation.BMJ open sport & exercise medicine · 2025Article
- Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis.Heliyon · 2024Article
- Sarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2024Article
- Association of Muscle Mass Loss with Diabetes Development in Liver Transplantation Recipients.Diabetes & metabolism journal · 2024Article
- Allograft function and muscle mass evolution after kidney transplantation.Journal of cachexia, sarcopenia and muscle · 2022Article
- Liver cirrhosis and sarcopenia: a dreadful combination.Hepatobiliary surgery and nutrition · 2022Article
- Non-Selective Beta-Blockers Decrease Infection, Acute Kidney Injury Episodes, and Ameliorate Sarcopenic Changes in Patients with Cirrhosis: A Propensity-Score Matching Tertiary-Center Cohort Study.Journal of clinical medicine · 2021Article
- Sarcopenia and mortality in different clinical conditions: A meta-analysis.Osteoporosis and sarcopenia · 2021Article
- Does Modern Lifestyle Favor Neuroimmunometabolic Changes? A Path to Obesity.Frontiers in nutrition · 2021Review
- Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis.Journal of gastrointestinal oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis is a risk factor for the loss of muscle mass, which is associated with numerous adverse health outcomes. This meta-analysis aimed to examine whether loss of muscle mass was a predictor of increased mortality in cirrhotic patients without or before liver transplantation.
methodsWithout language restriction, PubMed and Embase were searched for articles published from the earliest records to December 2018 investigating the influence of loss of muscle mass on survival of cirrhotic patients. Those who had undergone liver transplantation and had hepatocellular carcinoma were excluded. The main outcome was the hazard ratio (HR) for the association of mortality with loss of muscle mass, and the secondary outcome was the association of loss of muscle mass with Child-Pugh class and death caused by severe infection.
resultsThe meta-analysis included 16 observational studies, comprising 4070 participants. The pooled crude and adjusted HRs for the association of mortality with loss of muscle mass were 2.05 (95% confidence interval [CI], 1.51-2.78) and 2.36 (95% CI, 1.61-3.46). Using Child-Pugh Class A as reference, the odds ratios (ORs) for the association of loss of muscle mass with Child-Pugh Class B and Class C were 1.68 (95% CI, 0.96-2.92) and 1.94 (95% CI, 0.66-5.65). Patients with loss of muscle mass were likely to have infection-related mortality (OR = 3.38, 95% CI, 0.61-18.88) but the association did not reach statistical significance.
conclusionsLoss of muscle mass is associated with mortality in cirrhotic patients without or before liver transplantation. Future studies should be conducted to explore whether exercise and nutritional supplementation can reverse muscle mass loss and improve long-term survival.
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