Evidence map›Paper›PMID 30817226›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Macrophage migration inhibitory factor regulates innate γδ T-cell responses

Hee Kyung Kim, Alvaro Baeza Garcia, Edwin Siu, Pathricia Tilstam, Rita Das, Scott Roberts, Lin Leng, Richard Bucala

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. CD74 is a functional MIF receptor on activated CD4Cellular and molecular life sciences : CMLS · 2024
    Article
  2. Article
  3. MIF-Dependent Control of Tumor Immunity.Frontiers in immunology · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hee Kyung KimDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Alvaro Baeza GarciaDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Edwin SiuDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Pathricia TilstamDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Rita DasDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Scott RobertsDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Lin LengDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA; and.
Richard BucalaDepartment of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of Rheumatoid Synovial Fibroblast ActivationR01AR049610 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2002 to 2018
$5.0M
Aging and Innate Immune Mechanisms in Pulmonary InfectionR01HL130669 · NHLBI · YALE UNIVERSITY · PI BUCALA, RICHARD J, GOLDSTEIN, DANIEL ROBERT · 2015 to 2018
$1.7M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL130669NIAMS NIH HHS R01 AR049610
6 · The paper itself

Abstract

T cells expressing invariant γδ antigen receptors (γδ T cells) bridge innate and adaptive immunity and facilitate barrier responses to pathogens. Macrophage migration inhibitory factor (MIF) is an upstream mediator of host defense that up-regulates the expression of pattern recognition receptors and sustains inflammatory responses by inhibiting activation-induced apoptosis in monocytes and macrophages. Surprisingly,

Indexed as

AnimalsBacterial ToxinsEnterotoxinsImmunity, InnateInflammationInterleukin-17Intramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMycobacterium bovisReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinShock, SepticBacterial Toxinsenterotoxin F, StaphylococcalEnterotoxinsIl17a protein, mouseInterleukin-17interleukin-23 receptor, mouseIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMif protein, mouseReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinSuperantigensMIFTSST-1

Identifiers

PMID30817226
PMCPMC6529351
OpenAlexW2919690114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.