Evidence map›Paper›PMID 30817056›Full record

ReviewJournal of leukocyte biology2019

Long noncoding RNAs and the regulation of innate immunity and host-virus interactions.

Megha Basavappa, Sara Cherry, Jorge Henao-Mejia

Abstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Roles of lncRNAs in influenza virus infection.Emerging microbes & infections · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megha BasavappaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sara CherryDepartment of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jorge Henao-MejiaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Regulation of short-lived myeloid cells by the novel long non-coding RNA MorrbidR01HL136572 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE · 2017 to 2021
$2.0M
Antiviral immunity in the gut: how the intestinal epithelium and microbiota regulate infectionR01AI122749 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2016 to 2020
$2.0M
Regulation of adipose tissue inflammation by the miR-181 familyR21DK111755 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE · 2016 to 2018
$604k
Regulation of group 1 ILCs by a novel lncRNAR21AI128060 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE · 2017 to 2018
$443k
NHLBI NIH HHS R01 HL136572NIAID NIH HHS R01 AI122749NIAID NIH HHS R21 AI128060NIDDK NIH HHS R21 DK111755
6 · The paper itself

Abstract

Immune responses are both pathogen and cell type-specific. The innate arm of immunity is characterized by rapid intracellular signaling cascades resulting in the production of hundreds of antimicrobial effectors that protect the host organism. Long noncoding RNAs have been shown to operate as potent modulators of both RNA and protein function throughout cell biology. Emerging data suggest that this is also true within innate immunity. LncRNAs have been shown to regulate both innate immune cell identity and the transcription of gene expression programs critical for innate immune responses. Here, we review the diverse roles of lncRNAs within innate defense with a specific emphasis on host-virus interactions.

Indexed as

Immunity, InnateAnimalsCell DifferentiationHomeostasisHost Microbial InteractionsHumansRNA, Long NoncodingSignal TransductionRNA, Long Noncodinggene regulationhost-virus interactionsInnate immunitylong noncoding RNAs

Identifiers

PMID30817056
PMCPMC7050430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.