Evidence map›Paper›PMID 30816944›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2020

Gray Matter Volume Covariance Networks, Social Support, and Cognition in Older Adults.

Kelly Cotton, Joe Verghese, Helena M Blumen

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Correlates and Brain Substrates of Happiness in Community-Dwelling Older Adults in India.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  4. Article
  5. Longitudinal Associations of Social Support and Gait Speed Decline in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  6. Article
  7. Article
  8. Social Networks and Cognitive Reserve: Network Structure Moderates the Association Between Amygdalar Volume and Cognitive Outcomes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Greater Social Engagement and Greater Gray Matter Microstructural Integrity in Brain Regions Relevant to Dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kelly CottonDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Helena M BlumenDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York.

Funding

Biological and neural mechanisms of fallsR01AG044007 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2013 to 2017
$3.5M
Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
Motor Imagery: A Pilot Intervention for Improving Gait and Cognition in the ElderlyK01AG049829 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BLUMEN, HELENA M · 2016 to 2019
$522k
NIA NIH HHS K01 AG049829NIA NIH HHS R01 AG036921NIA NIH HHS R01 AG044007
6 · The paper itself

Abstract

objectiveWe examined the neural substrates of social support in older adults. Social support is associated with better outcomes in many facets of aging-including cognitive and functional health-but the underlying neural substrates remain largely unexplored.

methodsVoxel-based morphometry and multivariate statistics were used to identify gray matter volume covariance networks associated with social support in 112 older adults without dementia (M age = 74.6 years, 50% female), using the Medical Outcomes Study Social Support Survey.

resultsA gray matter network associated with overall social support was identified and included prefrontal, hippocampal, amygdala, cingulate, and thalamic regions. A gray matter network specifically associated with tangible social support (e.g., someone to help you if you were confined to bed) was also identified, included prefrontal, hippocampal, cingulate, insular, and thalamic regions, and correlated with memory and executive function. DISCUSSION: Gray matter networks associated with overall and tangible social support in this study were composed of regions previously associated with memory, executive function, aging, and dementia. Longitudinal research of the interrelationships between social support, brain structure, and cognition is needed, but strengthening social support may represent a new path toward improving cognition in aging that should be explored.

Indexed as

AgingGray MatterSocial SupportAgedCognitionExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleMemoryNerve NetNeuroimagingNeuropsychological TestsOrgan SizeExecutive functionMemoryMultivariate statisticsNeuroimagingSocial support

Identifiers

PMID30816944
PMCPMC7265803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.