ArticleJournal of cellular biochemistry2019
P53: The endothelium defender.
Article in Journal of cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Exploring the pathogenesis of acute lung injury and its treatment through Traditional Chinese Medicine: a state-of-the-art review.Frontiers in pharmacology · 2025Review
- Activating transcription factor 6 protects against endothelial barrier dysfunction.Cellular signalling · 2022Article
- Unfolded protein response in endothelial injury.Cell cycle (Georgetown, Tex.) · 2022Article
- Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis.Tissue barriers · 2021Article
- Unfolded Protein Response: A Regulator of the Endothelial Barrier.Endocrine and metabolic science · 2021Article
- P53 deficiency potentiates LPS-Induced acute lung injuryCurrent research in physiology · 2020Article
- P53 in the impaired lungs.DNA repair · 2020Review
- P53 in acute respiratory distress syndrome.Cellular and molecular life sciences : CMLS · 2020Article
- A glimpse at growth hormone-releasing hormone cosmos.Clinical and experimental pharmacology & physiology · 2020Article
- P53 is Subjected to Lipoteichoic Acid-Induced Phosphorylation in the Lungs.TH open : companion journal to thrombosis and haemostasis · 2020Article
- Effects of Heat Shock Protein 90 Inhibition In the Lungs.Medicine in drug discovery · 2020Article
- P53 Regulates the Redox Status of Lung Endothelial Cells.Inflammation · 2020Article
- P53 versus inflammation: an update.Cell cycle (Georgetown, Tex.) · 2020Review
- Unfolded Protein Response in Lung Health and Disease.Frontiers in medicine · 2020Article
- P53 in lung vascular barrier dysfunction.Vascular biology (Bristol, England) · 2020Article
- Unfolded Protein Response supports endothelial barrier function.Biochimie · 2019Review
- Unfolded protein response regulates P53 expression in the pulmonary endothelium.Journal of biochemical and molecular toxicology · 2019Article
- P53 supports endothelial barrier function via APE1/Ref1 suppression.Immunobiology · 2019Article
- GHRH antagonists support lung endothelial barrier function.Tissue barriers · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
P53 represents the paradigm of a multitalented transcription factor, responsible for the cellular defense against a plethora of potentially harmful stimuli. It exercises the ability to strongly oppose both cancer and inflammation, partially due to the fact that both conditions are highly interrelated. Endothelium hyperpermeability is considered the hallmark of severe lung inflammation, and the cardinal feature of the lethal acute respiratory distress syndrome. An emerging body of evidence suggests a strategic role of P53 towards vascular barrier integrity. The "endothelium defender" orchestrates meticulously devised responses; to counteract toxin-induced destructions of endothelium monolayers. The present effort seeks to further our understanding on the expanding P53 universe, discussing the most recent information regarding the involvement of that molecule in the pulmonary function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.