Evidence map›Paper›PMID 30816540›Full record

ArticleMolecular medicine reports2019

miR‑17‑5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog.

Xiaoyuan Wang, Zhijian Li, Jie Bai, Wuqi Song, Fengmin Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

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  8. Long non-coding RNA SNHG11 regulates the Wnt/β-catenin signaling pathway through rho/ROCK in trabecular meshwork cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  9. Long Non-coding RNA GAS5 Knockdown Attenuates HJournal of molecular neuroscience : MN · 2022
    Article
  10. The role of microRNAs in glaucoma.Experimental eye research · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaoyuan WangDepartment of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Zhijian LiDepartment of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Jie BaiDepartment of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Wuqi SongDepartment of Microbiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory of Infection and Immunity, Key Laboratory of Pathogenic Biology, Harbin, Heilongjiang 150086, P.R. China.
Fengmin ZhangDepartment of Microbiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory of Infection and Immunity, Key Laboratory of Pathogenic Biology, Harbin, Heilongjiang 150086, P.R. China.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is one of the leading causes of blindness. Previous studies have indicated that the oxidative stress‑induced apoptosis of trabecular meshwork cells (TMCs) may serve a key role in the pathogenesis of glaucoma, and that micro RNA(miR)‑17‑5p may be involved in this process. However, the specific mechanisms require further investigation. The aim of the present study was to investigate the effects of miR‑17‑5p on the proliferation and apoptosis of human TMCs (HTMCs) in response to oxidative stress. It was observed that exposure to H2O2 induced a significant decrease in the proliferation and a marked increase in the apoptosis of HTMCs. H2O2 exposure also suppressed the expression of miR‑17‑5p and promoted the expression of phosphatase and tensin homolog (PTEN). Furthermore, transient overexpression of miR‑17‑5p induced a significant increase in the proliferation and a significant decrease in the apoptosis of HTMCs by affecting the expression of PTEN, and the apoptosis‑related proteins B‑cell lymphoma‑associated X protein (Bax), B‑cell lymphoma‑extra large (Bcl‑xL) and B‑cell lymphoma‑2 (Bcl‑2). However, knockdown of miR‑17‑5p demonstrated the opposite results. The results of a dual luciferase reporter assay demonstrated that PTEN may be a direct target of miR‑17‑5p. In conclusion, miR‑17‑5p was downregulated in HTMCs under oxidative conditions, and miR‑17‑5p may regulate the apoptosis of HTMCs by targeting PTEN. These results provide a novel theoretical basis and potential therapeutic target for the treatment of glaucoma.

Indexed as

RNA InterferenceApoptosisCell ProliferationGene Expression RegulationHumansMicroRNAsOxidative StressPTEN PhosphohydrolaseTrabecular MeshworkMicroRNAsMIRN17 microRNA, humanPTEN PhosphohydrolasePTEN protein, human

Identifiers

PMID30816540
PMCPMC6423565
OpenAlexW2917980751

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.