ArticleScientific reports2019
Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Reservoirs and transmission routes of leprosy; A systematic review.PLoS neglected tropical diseases · 2020Pooled it
- UndetectableOne health (Amsterdam, Netherlands) · 2026Article
- M. leprae, M. lepromatosis, and Leprosy: Surprises and Surmises.The American journal of tropical medicine and hygiene · 2026Article
- Seroprevalence ofThe Lancet regional health. Southeast Asia · 2026Article
- Leprosy in the Americas before Columbus.Nature ecology & evolution · 2025Article
- Hansen's Disease in Ecuador: Current Status, Knowledge Gaps, and Research Priorities: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Advancing Mycobacterium leprae transmission research: Insights from the R2STOP fund.PLoS neglected tropical diseases · 2025Article
- Pilot study on seasonal variability in microbial contamination in the developing tourist region of Mindo, Ecuador: a comparative analysis of the Saguambi, Mindo, and Canchupí Rivers.BMC research notes · 2025Article
- Beyond the surface: Distinguishing leprosy from fungal mimics - A case report.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Leprosy.Nature reviews. Disease primers · 2024Review
- Molecular and Serological Surveillance forAnimals : an open access journal from MDPI · 2024Article
- Mycobacterium leprae in Armadillo Tissues from Museum Collections, United States.Emerging infectious diseases · 2023Article
- Innovative Therapeutic Approaches Based on Nanotechnology for the Treatment and Management of Tuberculosis.International journal of nanomedicine · 2023Review
- Global leprosy scenario: Eradication, elimination or control?The Indian journal of medical research · 2023Article
- Detection of Mycobacterium leprae DNA in clinical and environmental samples using serological analysis and PCR.Molecular biology reports · 2021Article
- Article
- Lepra Bubalorum, a Potential Reservoir ofFrontiers in microbiology · 2021Review
- Review
- Real-time PCR-based quantitation of viable Mycobacterium leprae strain from clinical samples and environmental sources and its genotype in multi-case leprosy families of India.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy is an infectious disease caused by Mycobacterium leprae affecting the skin and nerves. Despite decades of availability of adequate treatment, transmission is unabated and transmission routes are not completely understood. Despite the general assumption that untreated M. leprae infected humans represent the major source of transmission, scarce reports indicate that environmental sources could also play a role as a reservoir. We investigated whether M. leprae DNA is present in soil of regions where leprosy is endemic or areas with possible animal reservoirs (armadillos and red squirrels). Soil samples (n = 73) were collected in Bangladesh, Suriname and the British Isles. Presence of M. leprae DNA was determined by RLEP PCR and genotypes were further identified by Sanger sequencing. M. leprae DNA was identified in 16.0% of soil from houses of leprosy patients (Bangladesh), in 10.7% from armadillos' holes (Suriname) and in 5% from the habitat of lepromatous red squirrels (British Isles). Genotype 1 was found in Bangladesh whilst in Suriname the genotype was 1 or 2. M. leprae DNA can be detected in soil near human and animal sources, suggesting that environmental sources represent (temporary) reservoirs for M. leprae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.