ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Associations of the ages at menarche and menopause with blood pressure and hypertension among middle-aged and older Chinese women: a cross-sectional analysis of the baseline data of the China Health and Retirement Longitudinal Study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Female-specific hypertension risk factors across the lifecourse: a co-twin control analysis using the California Twin Program.American journal of epidemiology · 2026Article
- Early menarche and late menopause and their association with hypertension among Bangladeshi women: a community-based cross-sectional study in Dhaka, Bangladesh.BMC women's health · 2026Article
- Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.International journal of obesity (2005) · 2025Article
- Body Mass Index and Hypertension as Mediators of the Association Between Age at Menarche and Subclinical Atherosclerosis: A Sex-Specific Mendelian Randomization Analysis.Journal of the American Heart Association · 2024Article
- Reproductive factors and their association with physical and comprehensive frailty in middle-aged and older women: a large-scale population-based study.Human reproduction open · 2024Article
- Late age at menopause positively associated with obesity-mediated hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Obesity indicators as mediators of the association between age at menopause and blood pressure values.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Mediation Effect of Obesity on the Association of Age at Menarche With Blood Pressure Among Women in Southwest China.Journal of the American Heart Association · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- The association between early menarche and higher-risk cardiometabolic profile: a dose-response analysis of the Tabari cohort at enrollment phase.Frontiers in cardiovascular medicine · 2023Article
- Article
- Associations between Age at Menarche and Dietary Patterns with Blood Pressure in Southwestern Chinese Adults.Nutrients · 2022Article
- Reproductive lifespan in association with risk of hypertension among Chinese postmenopausal women: Results from a large representative nationwide population.Frontiers in cardiovascular medicine · 2022Article
- Age at Natural Menopause and Blood Pressure Traits: Mendelian Randomization Study.Journal of clinical medicine · 2021Article
- Age at menarche and risk of hypertension in Chinese adult women: Results from a large representative nationwide population.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Association between Age at Menarche and Hypertension among Females in Southern China: A Cross-Sectional Study.International journal of hypertension · 2019Article
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9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the associations of the ages at menarche and menopause with blood pressure (BP) and hypertension using the baseline data of 7893 women from the China Health and Retirement Longitudinal Study, a nationally representative survey among Chinese adults aged ≥45 years. Multivariate linear and logistic regression analyses were performed to evaluate the associations of the ages at menarche and men`opause with BP and hypertension, respectively. Nonlinear associations were evaluated using spline analyses. After controlling for age, education, marital status, living areas, smoking, drinking, and medication use if necessary, an early onset of menarche by 1 year was associated with a 6% (95% confidence interval [CI]: 3-9%) higher odds of hypertension and 0.82 mm Hg (P < 0.001) and 0.41 mm Hg (P < 0.001) higher systolic and diastolic BP, respectively. When further controlling for the body mass index (BMI), blood glucose, and lipids, the associations were still significant. Spline analyses did not support U-shaped relationships between menarche age and hypertension risk (P = 0.35), systolic BP (P = 0.60), or diastolic BP (P = 0.70). When stratified by location of residence, menarche age was only associated with BP and hypertension among women living in rural areas. The age of menopause was positively associated with hypertension (odds ratio [OR] = 1.02 per year delay of menopause, 95% CI: 1.01-1.03). However, when further controlling for BMI, such an association no longer existed (OR = 1.01, P = 0.32). These findings indicated that the associations of menarche age with BP and hypertension may be modified by factors related to the area of residence in China, and the association between menopause age and hypertension was driven by BMI.
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