ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Altered PAPP-A and Placental Thickness in Pre-Eclampsia and Intrauterine Growth Restriction: A Pilot Study.Journal of clinical medicine · 2026Article
- NFĸB and its inhibitors in preeclampsia: mechanisms and potential interventions.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Cell type and cell signalling innovations underlying mammalian pregnancy.Nature ecology & evolution · 2025Article
- PAPPA's role in female reproduction.Reproduction (Cambridge, England) · 2025Review
- AC092100.1 promotes angiogenesis in pre-eclampsia through YTHDC2/VEGFA signaling.Functional & integrative genomics · 2024Article
- Placental Origins of Preeclampsia: Insights from Multi-Omic Studies.International journal of molecular sciences · 2024Review
- Development and validation of preeclampsia predictive models using key genes from bioinformatics and machine learning approaches.Frontiers in immunology · 2024Article
- Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis.BMC medicine · 2023Article
- Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients.American journal of obstetrics and gynecology · 2022Article
- Fear Stress During Pregnancy Affects Placental m6A-Modifying Enzyme Expression and Epigenetic Modification Levels.Frontiers in genetics · 2022Article
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- Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling.BioMed research international · 2021Article
- PAPP-A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia.Journal of the American Heart Association · 2020Observational
- Aberrant hydroxymethylation ofEpigenetics · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compromised placentation strongly predisposes to preeclampsia (PE) which is a severe complication of pregnancy. Pregnancy-associated plasma protein-A2 (PAPP-A2) has higher expression in the placenta than in any other tissues. However, the possible role of PAPP-A2 in placental development and in the pathogenesis of PE remains unclear. In this study, we aimed at exploring placental expression of PAPP-A2 in early- and late-onset of severe PE and its role in the mechanism inducing the development of PE. We found that expression of PAPP-A2 mRNA and protein was elevated in placentas from women with severe PE compared to control placentas and was localized to differentiated trophoblasts; higher in early-onset PE than that in late-onset PE. PAPP-A2 was expressed in the cytoplasm of both primary trophoblasts and HTR-8/SVneo cells. Elevated PAPP-A2 attenuated migration, invasion, explant outgrowth and network formation of trophoblast cells in vitro without affecting cell proliferation and apoptosis. PAPP-A2 attenuated trophoblast invasion and migration by restraining epithelial-mesenchymal translations via downregulation of the Hedgehog signaling pathway. Overall, the increased expression of placental PAPP-A2 is specific to different period of PE onset and PAPP-A2 may contribute to poor placentation and inadequate angiogenesis thereby leading to the development of preeclampsia.
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