ArticleScientific reports2019
Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure inFrontiers in nutrition · 2026Article
- Persistent maternal age effects on male offspring fitness traits in a wild mammal population.Evolution letters · 2025Article
- Reproductive-Triggered Sterol Competition Exacerbates Age-Related Intestinal Barrier Damage in Drosophila Females.Aging cell · 2025Article
- Mate-switching is not associated with offspring fitness in a socially monogamous bird.Proceedings. Biological sciences · 2025Article
- Maternal effect senescence and caloric restriction interact to affect fitness through changes in life history timing.The Journal of animal ecology · 2025Article
- Article
- Response of fruit fly (Physiological entomology · 2024Article
- A demographic assessment of the Lansing Effect in duckweed (Lemna turionifera Landolt).Biology letters · 2024Article
- Maternal age effects on offspring lifespan and reproduction vary within a species.Ecology and evolution · 2024Article
- Sex-dependent effects of parental age on offspring fitness in a cooperatively breeding bird.Evolution letters · 2022Article
- The Contributions of Maternal Age Heterogeneity to Variance in Lifetime Reproductive Output.The American naturalist · 2022Article
- The Genome of the Marine Rotifer Brachionus manjavacas: Genome-Wide Identification of 310 G Protein-Coupled Receptor (GPCR) Genes.Marine biotechnology (New York, N.Y.) · 2022Article
- The role of maternal age, growth, and environment in shaping offspring performance in an aerial conifer seed bank.American journal of botany · 2022Article
- A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds.Biogerontology · 2021Article
- Beneficial cumulative effects of old parental age on offspring fitness.Proceedings. Biological sciences · 2021Article
- Centenarians exposed to the Spanish flu in their early life better survived to COVID-19.Aging · 2021Article
- Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging.Nutrition and healthy aging · 2021Review
- Article
- A demographic and evolutionary analysis of maternal effect senescence.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Maternal age has a negative effect on offspring lifespan in a range of taxa and is hypothesized to influence the evolution of aging. However, the mechanisms of maternal age effects are unknown, and it remains unclear if maternal age alters offspring response to therapeutic interventions to aging. Here, we evaluate maternal age effects on offspring lifespan, reproduction, and the response to caloric restriction, and investigate maternal investment as a source of maternal age effects using the rotifer, Brachionus manjavacas, an aquatic invertebrate. We found that offspring lifespan and fecundity decline with increasing maternal age. Caloric restriction increases lifespan in all offspring, but the magnitude of lifespan extension is greater in the offspring from older mothers. The trade-off between reproduction and lifespan extension under low food conditions expected by life history theory is observed in young-mother offspring, but not in old-mother offspring. Age-related changes in maternal resource allocation to reproduction do not drive changes in offspring fitness or plasticity under caloric restriction in B. manjavacas. Our results suggest that the declines in reproduction in old-mother offspring negate the evolutionary fitness benefits of lifespan extension under caloric restriction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.