Evidence map›Paper›PMID 30816234›Full record

ArticleScientific reports2019

Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia.

Wan-Young Kim, Sun Ah Nam, Arum Choi, Yu-Mi Kim, Sang Hee Park, Hong Lim Kim, Hyang Kim, Ki-Hwan Han, Chul Woo Yang, Myung-Shik Lee and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026
    Review
  2. Article
  3. Vasopressin-Sensitive Aqp2 Regulation Mediated by the TAZ-NR4A1 Axis in Renal Collecting Duct Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
  5. Autophagy and regulation of aquaporins in the kidneys.Kidney research and clinical practice · 2023
    Article
  6. Autophagy and Its Lineage-Specific Roles in the Hematopoietic System.Oxidative medicine and cellular longevity · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Rapid development of vasopressin resistance in dietary KAmerican journal of physiology. Renal physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Wan-Young KimDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sun Ah NamDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Arum ChoiDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yu-Mi KimDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sang Hee ParkInstitute of Clinical Medicine Research of Bucheon St. Mary's Hospital, Bucheon, Korea.
Hong Lim KimIntegrative Research Support Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyang KimDivision of Nephrology, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
Ki-Hwan HanDepartment of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.
Chul Woo YangDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Myung-Shik LeeSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Korea.ORCID 0000-0003-3292-1720
Yong Kyun KimDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. drkimyk@catholic.ac.kr.
Jin KimDepartment of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. jinkim@catholic.ac.kr.
Catholic University of Korea · KRKangbuk Samsung Hospital · KREwha Womans University · KRThe Catholic University of Korea Bucheon St. Mary's Hospital · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged hypokalemia induces a decrease of urinary concentrating ability via down-regulation of aquaporin 2 (AQP2); however, the precise mechanisms remain unknown. To investigate the role of autophagy in the degradation of AQP2, we generated the principal cell-specific Atg7 deletion (Atg7

Indexed as

AnimalsAquaporin 2AutophagyAutophagy-Related Protein 7Down-RegulationHypokalemiaKidneyMaleMiceMicrotubule-Associated ProteinsPhosphorylationrab GTP-Binding ProteinsAqp2 protein, mouseAquaporin 2Atg7 protein, mouseAutophagy-Related Protein 7Microtubule-Associated Proteinsrab GTP-Binding Proteins

Identifiers

PMID30816234
PMCPMC6395725
OpenAlexW2917693421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.