Evidence map›Paper›PMID 30816091›Full record

ArticleeLife2019

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

Bradley Quade, Marcial Camacho, Xiaowei Zhao, Marta Orlando, Thorsten Trimbuch, Junjie Xu, Wei Li, Daniela Nicastro, Christian Rosenmund, Josep Rizo

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 118 citations in OpenAlex.

  1. Article
  2. Article
  3. Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Synaptic transmission: Munc13 assembles onto PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Munc13-1 couples DAG and CaScience advances · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Nanoscale architecture of synaptic vesicles and scaffolding complexes revealed by cryo-electron tomography.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Bradley Quade *Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Marcial Camacho *Institut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-2367-1259
Xiaowei ZhaoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Marta OrlandoInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.
Thorsten TrimbuchInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.
Junjie XuDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Wei LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Daniela NicastroDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-0122-7173
Christian RosenmundInstitut für Neurophysiologie, Charité - Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-3905-2444
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0003-1773-8311
The University of Texas Southwestern Medical Center · USCharité - Universitätsmedizin Berlin · DE

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
Molecular Biophysics Predoctoral Training ProgramT32GM008297 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHOOK, YUH MIN · 1989 to 2018
$2.4M
Acquisition of upgrades for 800 MHz NMR consoleS10OD018027 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2014 to 2014
$376k
Deutsche Forschungsgemeinschaft 8-1Deutsche Forschungsgemeinschaft Ro1296/7-1Deutsche Forschungsgemeinschaft Ro1296/8-1Deutsche Forschungsgemeinschaft SFB 1315Deutsche Forschungsgemeinschaft SFB958NIGMS NIH HHS T32 GM008297NIH HHS S10 OD018027NIH HHS S10OD018027NINDS NIH HHS R35 NS097333Welch Foundation I-1304
6 · The paper itself

Abstract

Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C

Indexed as

AnimalsCell MembraneCells, CulturedCytoplasmic VesiclesIntracellular MembranesMiceNerve Tissue ProteinsNeuronsNeurotransmitter AgentsRatsNerve Tissue ProteinsNeurotransmitter AgentsUnc13a protein, mousemembrane bridgingmolecular biophysicsmouseMunc13neuroscienceneurotransmitter releasereconstitutionstructural biologysynaptic vesicle dockingsynaptic vesicle fusion

Identifiers

PMID30816091
PMCPMC6407922
OpenAlexW2917060214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.