Evidence map›Paper›PMID 30815998›Full record

Trial reportBrain and behavior2019

BIS-guided deep anesthesia decreases short-term postoperative cognitive dysfunction and peripheral inflammation in elderly patients undergoing abdominal surgery.

Chengxuan Quan, Jia Chen, Yuting Luo, Lei Zhou, Xi He, Yan Liao, Jing Chou, Qulian Guo, Alex F Chen, Ouyang Wen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07479719 (Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 55 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 4 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07479719 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery: a Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled200ConditionsElderly, Surgery, Depth of Anesthesia, Total Intravenous AnesthesiaArmsLight anesthesia, Deep anesthesia
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Chengxuan QuanDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0002-8240-840X
Jia ChenDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Yuting LuoDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Lei ZhouDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Xi HeDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Yan LiaoDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Jing ChouDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Qulian GuoDepartment of Anesthesia, Xiangya Hospital of Central South University, Changsha, China.
Alex F ChenDepartment of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, China.
Ouyang WenDepartment of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPostoperative cognitive dysfunction (POCD) is a common clinical complication, with an underlying pathophysiology linked to heightened levels of neuroinflammation. However, it requires clarification as to whether the depth of anesthesia modulates postoperative cognitive dysfunction. This study investigated the association between depth of anesthesia and POCD in elderly patients undergoing abdominal surgery.

methodsA total of 120 patients aged 60 years or older who were planned for abdominal surgery under total intravenous anesthesia were included in this study. The depth of anesthesia was guided by monitoring Bispectral Index (BIS) data. All study participants completed a battery of nine neuropsychological tests before surgery and at 7 days and 3 months after surgery. POCD was calculated by using the reliable change index. Plasma concentration of C-reactive protein (CRP), interleukin (IL)-1β, IL-10, S-100β, and norepinephrine (NE) were measured.

resultsThe incidence of POCD at 7 days after surgery in the deep anesthesia group was 19.2% (10/52), which was significantly lower (p = 0.032) than the light anesthesia group 39.6% (21/53). The depth of anesthesia had no effect on POCD at 3 months after surgery (10.3% vs 14.6%, respectively, p = 0.558). Similarly, plasma levels of CRP and IL-1β in deep anesthesia group were lower than that in light anesthesia group at 7 days after surgery (p < 0.05), but not at 3 months after surgery (p > 0.05). There were no significant differences in the plasma concentration of IL-10, S-100β, and NE between the groups (p > 0.05).

conclusionsDeep anesthesia under total intravenous anesthesia could decrease the occurrence of short-term POCD and inhibit postoperative peripheral inflammation in elderly patients undergoing abdominal surgery, compared with light anesthesia.

Indexed as

AbdomenAgedAnesthesia, GeneralAnesthetics, CombinedAnesthetics, IntravenousCognitive DysfunctionC-Reactive ProteinElectroencephalographyFemaleHumansInterleukin-10Interleukin-1betaMaleMiddle AgedNeuritisNeuropsychological TestsAnesthetics, CombinedAnesthetics, IntravenousC-Reactive ProteinIL10 protein, humanIL1B protein, humanInterleukin-10Interleukin-1betaS100 Calcium Binding Protein beta Subunitbispectral index (BIS)depth of anesthesiapostoperative cognitive dysfunction (POCD)total intravenous anesthesia

Identifiers

PMID30815998
PMCPMC6456817
OpenAlexW2919644963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.