ArticleBrain and behavior2019
Exploring the association between Cerebral small-vessel diseases and motor symptoms in Parkinson's disease.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Optical coherence tomography angiography measurements in Parkinson's disease: A systematic review and meta-analysis.Eye (London, England) · 2023Pooled it
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Discriminating vascular parkinsonism from early-stage postural instability gait difficulty subtype dominant Parkinson's disease: a dual-task gait analysis using wearable sensors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Associations between enlarged perivascular spaces and clinical manifestations: a meta-analysis.Archives of medical science : AMS · 2026Review
- Associations of white matter hyperintensity with frailty, sarcopenia, and nutritional risk: an analysis of an acute ischemic stroke patient database.Frontiers in medicine · 2025Article
- Deep Cascade of Convolutional Neural Networks for Quantification of Enlarged Perivascular Spaces in the Basal Ganglia in Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- White matter changes in Parkinson's disease.NPJ Parkinson's disease · 2023Review
- The impact of cerebral small vessel disease burden and its imaging markers on gait, postural control, and cognition in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Lacunes may worsen cognition but not motor function in Parkinson's disease.Brain and behavior · 2023Article
- Imaging perivascular space structure and function using brain MRI.NeuroImage · 2022Review
- Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease: a systematic review and meta-analysis.Annals of translational medicine · 2022Article
- Evolution characteristics of dynamic balance disorder over the course of PD and relationship with dopamine depletion.Frontiers in aging neuroscience · 2022Article
- The Correlation Between Modified Total Cerebral Small Vessel Disease Score and Gait and Balance Disorder in Middle-aged to Older Adults.Current neurovascular research · 2022Article
- The effect of regional white matter hyperintensities on essential tremor subtypes and severity.Frontiers in aging neuroscience · 2022Article
- Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study.Frontiers in neurology · 2022Article
- Correlation Between Lacunae and the Wearing-off Phenomenon in Parkinson's Disease.Neuropsychiatric disease and treatment · 2022Article
- Cognitive Performance is Associated with Altered Cerebral Hemodynamics Assessed by Transcranial Ultrasound in Parkinson's Disease.Neuropsychiatric disease and treatment · 2022Article
- Association of Cerebral Small Vessel Disease With Gait and Balance Disorders.Frontiers in aging neuroscience · 2022Review
- Enlarged perivascular spaces are linked to freezing of gait in Parkinson's disease.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesto explore the association between cerebral small-vessel diseases (CSVDs) and motor symptoms in Parkinson's disease (PD).
methods137 PD patients were recruited into the study. Detailed motor symptoms, including tremor, rigidity, bradykinesia, and axial impairment, were evaluated using Unified Parkinson's disease Rating Scale (UPDRS). Non-motor symptoms, including cognition, anxiety, and depression, were evaluated using Montreal Cognitive Assessment (MoCA), Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD). Brain MRI was used to assess the subtypes of CSVDs, including lacunes, enlarged perivascular spaces (EPVS), and white matter hyperintensities (WMH). WMH were furtherly divided into deep WMH (DWMH) and periventricular hyperintensities (PVH). The association between CSVDs and motor symptoms was analyzed. Patients were divided into the postural instability and gait disability (PIGD) group and non-PIGD group. Demographic, clinical and CSVDs variables were compared between the two groups.
resultsCSVDs subtypes were all detected in the participants with different prevalence rates and severity degrees. We found a close association between EPVS in basal ganglia and the tremor score (p = 0.032), and between DWMH in the frontal and occipital lobes and the axial motor score (p < 0.05) through the spearman and multivariate liner regression analysis. Compared with the non-PIGD group, the PIGD group demonstrated more serious cognitive impairment and DWMH in the frontal and occipital lobes (p < 0.05). The demographic characteristics and vascular risk factors of the PIGD group were not different from those of the non-PIGD group. Cognitive impairment and DWMH in the frontal lobe were identified to be independent risk factors of PIGD motor phenotype.
conclusionsWe identified a close association between the CSVDs and motor symptoms in PD and DWMH in the frontal lobe was a risk factor of PIGD motor phenotype, which supports the contribution of vascular pathology in PD.
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