Evidence map›Paper›PMID 30815847›Full record

ArticleClinical pharmacokinetics2019

Differences in Warfarin Pharmacodynamics and Predictors of Response Among Three Racial Populations.

Minami Ohara, Yasuhiko Suzuki, Saki Shinohara, Inna Y Gong, Crystal L Schmerk, Rommel G Tirona, Ute I Schwarz, Ming-Shien Wen, Ming Ta Michael Lee, Kiyoshi Mihara and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical pharmacokinetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Geographic Disparities in Evidence Investigating the Use of Biologics in Chronic Rhinosinusitis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Racial Disparity in Drug Disposition in the Digestive Tract.International journal of molecular sciences · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Minami OharaDepartment of Biopharmaceutics, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, 204-8588, Japan.
Yasuhiko SuzukiDepartment of Biopharmaceutics, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, 204-8588, Japan.
Saki ShinoharaDepartment of Biopharmaceutics, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, 204-8588, Japan.
Inna Y GongDivision of Clinical Pharmacology, University of Western Ontario, London, ON, Canada.
Crystal L SchmerkDivision of Clinical Pharmacology, University of Western Ontario, London, ON, Canada.
Rommel G TironaDivision of Clinical Pharmacology, University of Western Ontario, London, ON, Canada.
Ute I SchwarzDivision of Clinical Pharmacology, University of Western Ontario, London, ON, Canada.
Ming-Shien WenDepartment of Internal Medicine, Linkou and Chang Gung University College of Medicine, Tauyuan, Taiwan.
Ming Ta Michael LeeGenomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
Kiyoshi MiharaFaculty of Pharmacy, Center for Clinical Pharmacy, Musashino University, Tokyo, Japan.
Edith A NutescuDepartment of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, USA.
Minoli A PereraDepartment of Pharmacology, Northwestern University, Chicago, IL, USA.
Larisa H CavallariDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, University of Florida, Gainesville, FL, USA.
Richard B KimDivision of Clinical Pharmacology, University of Western Ontario, London, ON, Canada.
Harumi TakahashiDepartment of Biopharmaceutics, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, 204-8588, Japan. harumit@my-pharm.ac.jp.
Western University · CAMeiji Pharmaceutical University · JPChang Gung University · TWGeisinger Health System · USMusashino University · JPNorthwestern University · USUniversity of Florida · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPopulation differences in warfarin dosing requirement have been reported; however, unlike the pharmacokinetics (PK) of warfarin, the quantitative influences of pharmacodynamic (PD) factors on the anticoagulation response to warfarin in different ethnic populations are totally unknown.

methodsUsing population PK/PD analysis, we attempted to identify predictors of S-warfarin clearance [CL(S)] and half maximal effective concentration (EC

resultsSimilar to our previous findings, the median CL(S) was 30% lower in African American patients than Asian and White patients (169 vs. 243 and 234 mL/h, p < 0.01). EC

conclusionsAlthough there were contrasting racial differences in CL(S) and EC

Indexed as

AgedAged, 80 and overAlgorithmsAnticoagulantsAsian PeopleBlack or African AmericanCase-Control StudiesCytochrome P-450 CYP2C9Evaluation Studies as TopicFemaleGenotypeHumansInternational Normalized RatioMaleMiddle AgedPharmacogeneticsAnticoagulantsCYP2C9 protein, humanCytochrome P-450 CYP2C9Vitamin K Epoxide ReductasesVKORC1 protein, humanWarfarin

Identifiers

PMID30815847
OpenAlexW2918993549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.