ArticleJournal of general internal medicine2019
Diabetes-Multimorbidity Combinations and Disability Among Middle-aged and Older Adults.
Article in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06358118 (Clinical Research on Evidence Based Traditional Chinese Medicine for Elderly Diabetes Based on State Target Theory-Buyuan Zhixiao Fang in the Treatment of Elderly Patients With Diabetes and Multiple Metabolic Disorders), which is not on this map. Cited by 43 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Research on Evidence Based Traditional Chinese Medicine for Elderly Diabetes Based on State Target Theory-Buyuan Zhixiao Fang in the Treatment of Elderly Patients With Diabetes and Multiple Metabolic Disorders: Study Protocol for a Multicenter, Randomized, Double-blind, Placebo-controlled Trial
Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- Socioeconomic mobility and the prevalence and incidence of difficulties in daily living in US Hispanic/Latino adults.Annals of epidemiology · 2026Article
- Arthritis-diabetes comorbidity and functional recovery in older adults: a longitudinal cohort study using the Health and Retirement Study.Research square · 2026Article
- Machine Learning Classification of Current Functional Impairment in Older Adults with Diabetes: Evidence from CHARLS 2015.Journal of clinical medicine · 2026Article
- Evaluating a novel recovery device in diabetic patients with knee osteoarthritis: protocol for a randomised controlled trial.BMJ open · 2026Article
- Associations of activities of daily living and their trajectories with the risk of diabetes-related lower-limb amputation: evidence from the HRS and ELSA longitudinal cohorts.Frontiers in endocrinology · 2026Article
- Clonal hematopoiesis of indeterminate potential: a multisystem hub bridging hematopoietic dysfunction with non-hematopoietic diseases.Military Medical Research · 2025Review
- New Technologies for Blood Glucose Management in Elderly Diabetics: An Interpretation of theAging medicine (Milton (N.S.W)) · 2025Review
- Associations of Physical Activity, Sedentary Behaviour, Pain, Function and Quality of Life With Diabetes and Knee Osteoarthritis: Data From the Osteoarthritis Initiative.Musculoskeletal care · 2025Article
- Examining the severity of disability and vulnerability among older adults and its impact on elder abuse: a cross-sectional study.Scientific reports · 2025Article
- Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank.BMJ public health · 2025Article
- Article
- Longitudinal sequencing of cardiometabolic multimorbidity among older adults and association with subsequent dementia onset.PloS one · 2025Article
- Management of older adults with diabetes mellitus: Perspective from geriatric medicine.Journal of diabetes investigation · 2024Review
- Self-Reported Diabetes in Older Adults: A Comparison of Prevalence and Related Factors in the Mexican Health and Aging Study (2015, 2018, and 2021).Journal of diabetes research · 2024Article
- The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China.Frontiers in aging neuroscience · 2024Article
- Prevalence and co-prevalence of comorbidities among Chinese adult patients with type 2 diabetes mellitus: a cross-sectional, multicenter, retrospective, observational study based on 3B study database.Frontiers in endocrinology · 2024Observational
- Letter to the editor: alarming prevalence of comorbid conditions in adults with type 2 diabetes in Iran.Journal of diabetes and metabolic disorders · 2023Article
- A network-based study reveals multimorbidity patterns in people with type 2 diabetes.iScience · 2023Article
- Segmenting Patients With Diabetes With the Navigator Service in Primary Care and a Description of the Self-Acting Patient Group: Cross-Sectional Study.Journal of medical Internet research · 2023Observational
- Social exclusion in people with diabetes: cross-sectional and longitudinal results from the German Ageing Survey (DEAS).Scientific reports · 2023Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOlder adults with diabetes rarely have only one chronic disease. As a result, there is a need to re-conceptualize research and clinical practice to address the growing number of older Americans with diabetes and concurrent chronic diseases (diabetes-multimorbidity).
objectiveTo identify prevalent multimorbidity combinations and examine their association with poor functional status among a nationally representative sample of middle-aged and older adults with diabetes.
designA prospective cohort study of the 2012-2014 Health and Retirement Study (HRS) data. We identified the most prevalent diabetes-multimorbidity combinations and estimated negative binomial models of diabetes-multimorbidity on prospective disability.
participantsAnalytic sample included 3841 HRS participants with diabetes, aged 51 years and older. MAIN MEASURES: The main outcome measure was the combined activities of daily living (ADL)-instrumental activities of daily living (IADL) index (range 0-11; higher index denotes higher disability). The main independent variables were diabetes-multimorbidity combination groups, defined as the co-occurrence of diabetes and at least one of six somatic chronic diseases (hypertension, cardiovascular disease, lung disease, cancer, arthritis, and stroke) and/or two mental chronic conditions (cognitive impairment and high depressive symptoms (CESD score ≥ 4). KEY
resultsThe three most prevalent multimorbidity combinations were, in rank-order diabetes-arthritis-hypertension (n = 694, 18.1%); diabetes-hypertension (n = 481, 12.5%); and diabetes-arthritis-hypertension-heart disease (n = 383, 10%). Diabetes-multimorbidity combinations that included high depressive symptoms or stroke had significantly higher counts of ADL-IADL limitations compared with diabetes-only. In head-to-head comparisons of diabetes-multimorbidity combinations, high depressive symptoms or stroke added to somatic multimorbidity combinations was associated with a higher count of ADL-IADL limitations (diabetes-arthritis-hypertension-high depressive symptoms vs. diabetes-arthritis-hypertension: IRR = 1.95 [1.13, 3.38]; diabetes-arthritis-hypertension-stroke vs. diabetes-arthritis-hypertension: IRR = 2.09 [1.15, 3.82]) even after adjusting for age, gender, education, race/ethnicity, BMI, baseline ADL-IADL, and diabetes duration. Coefficients were robust to further adjustment for diabetes treatment.
conclusionsDepressive symptoms or stroke added onto other multimorbidity combinations may pose a substantial functional burden for middle-aged and older adults with diabetes.
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