Evidence map›Paper›PMID 30815631›Full record

ArticleGeneral psychiatry2018

Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia.

Jinjie Xu, Yumei Jiao, Mengjuan Xing, Yezhe Lin, Yousong Su, Wenhua Ding, Cuizhen Zhu, Yanmin Peng, Dake Qi, Donghong Cui

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in General psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Association Between Abundance ofFrontiers in psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jinjie Xu *Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yumei Jiao *Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Mengjuan XingShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yezhe LinShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yousong SuShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Wenhua DingShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Cuizhen ZhuShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yanmin PengShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Dake QiShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Donghong CuiShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNMemorial University of Newfoundland · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia. OBJECTIVEAIMS: To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.

methodsCross-sectional studies were applied to (1) compare the levels of plasma leptin between schizophrenia (n=74) and healthy controls (n=50); and (2) investigate the relationship between plasma leptin levels and depressive subscores.

results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls. (2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS). (3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.

conclusionLeptin may serve as a predictor for the depressive symptoms of chronic schizophrenia.

Indexed as

chronic schizophreniadepressive symptomsleptin

Identifiers

PMID30815631
PMCPMC6371651
OpenAlexW2904790361

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.