ArticleEndocrinology, diabetes & metabolism2018
Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.
Article in Endocrinology, diabetes & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 8 citations in OpenAlex.
- Relation of glucose variability on mortality from any cause and cardiovascular diseases in individuals with type 2 diabetes: mediation analysis of echocardiographic parameters.BMC cardiovascular disorders · 2025Article
- A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis.Communications biology · 2024Article
- The Effect of Glycemic Control on Left Ventricular Function in Clinical and Experimental Diabetes.CJC open · 2023Article
- Pioglitazone reduces epicardial fat and improves diastolic function in patients with type 2 diabetes.Diabetes, obesity & metabolism · 2023Article
- Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function.Diagnostics (Basel, Switzerland) · 2021Review
- Sodium-glucose cotransporter 2 inhibitors represent a paradigm shift in the prevention of heart failure in type 2 diabetes patients.Journal of diabetes investigation · 2021Review
- An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes.BMC endocrine disorders · 2019Article
- Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.Endocrinology, diabetes & metabolism · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLeft ventricular (LV) diastolic dysfunction commonly is observed in individuals with type 2 diabetes mellitus (T2DM). We employed transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (CMRI) to investigate the hypothesis that LV diastolic dysfunction in T2DM is associated with poor glycemic control.
methodsForty subjects, 21 with normal glucose tolerance (NGT) and 19 with T2DM, were studied with CMRI and TTE to assess LV function. Early-to-late transmitral flow ratio (E/A) and deceleration time (DecT) were assessed with both modalities. Normalized (to body surface area) end-diastolic volume (EDV/BSA) and normalized peak LV filling rate (pLVFR/BSA) were assessed with CMRI. Early transmitral flow velocity to septal velocity (E/e') and isovolumetric relaxation time (IVRT) were measured using TTE. Dimensional parameters were normalized to body surface area (BSA).
resultsCMRI measurements demonstrated impaired E/A (1.13 ± 0.34 vs 1.62 ± 0.42,
conclusionsImpaired LV diastolic function (DF) was found in T2DM subjects with both CMRI and TTE, and multiple LVDF parameters correlated negatively with HbA1c and FPG. These results indicate that impaired LVDF is inversely linked to glycemic control in T2DM patients.
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