ArticleGynecologic oncology reports2019
Malignant Brenner tumor of the ovary: Case series and review of treatment strategies.
Article in Gynecologic oncology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- A Case of Malignant Brenner Tumor With High FDG Uptake.Clinical case reports · 2026Article
- Risk-adapted management of early-stage malignant Brenner tumor: eight-year outcomes and contemporary evidence review-a case report.Journal of medical case reports · 2026Review
- Uncommon Presentation of a Benign Brenner Tumor Mimicking Malignancy: A Case Report.Case reports in obstetrics and gynecology · 2026Article
- Malignant Brenner tumor with extensive clear cell features: A valuable diagnostic lesson learned from molecular tumor profiling and AI-based tumor differential tool.Gynecologic oncology reports · 2025Article
- Article
- Mature Teratoma with Malignant Brenner Tumour: A Rare Ovarian Collision Tumour Case Report and Literature Review.Journal of obstetrics and gynaecology of India · 2025Article
- Management of a Borderline Brenner Tumor of the Ovary in a Premenopausal Woman in Northern Tanzania. A Rare Case Report and Review of the Current Literature.Clinical case reports · 2024Article
- A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.BMC women's health · 2024Review
- Review
- Comparison of performance between O-RADS, IOTA simple rules risk assessment and ADNEX model in the discrimination of ovarian Brenner tumors.Archives of gynecology and obstetrics · 2023Article
- Coexistence of a huge Brenner's tumour and mucinous cystadenoma in a 62-year-old female: a case report from Syria.Annals of medicine and surgery (2012) · 2023Article
- A Rare Case of Ruptured Malignant Ovarian Brenner Tumor.The American journal of case reports · 2023Review
- Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature.Medical sciences (Basel, Switzerland) · 2023Review
- Thoracic spinal metastasis as recurrence of borderline Brenner tumor without local recurrence: A case report.Gynecologic oncology reports · 2022Article
- Thoracic spinal metastasis as recurrence of borderline Brenner tumor without local recurrence: A case report.Gynecologic oncology reports · 2022Article
- Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research.JCO clinical cancer informatics · 2020Article
- Bilateral Malignant Brenner Tumor of the Ovary.Case reports in oncologyArticle
- Points to Remember in Ovarian Eponyms Pearls: Dr. Fritz Malignant Brenner Tumor.Gynecology and minimally invasive therapyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant Brenner tumor (MBTs) is a rare histological subtype of epithelial ovarian cancer, accounting for <0.05% of all ovarian neoplasms. As such, current evidence on the treatment of MBTs is predominantly limited to case studies and small case series. To add to existing literature, we performed a retrospective review of 10 cases of MBT diagnosed and treated at a single institution between 1999 and 2018. For the 10 cases included in our cohort, the median age was 64 and the median tumor stage was IIa/IIb. All patients underwent either a primary or interval debulking surgery and achieved an R0 resection per classifications set by the Union for International Cancer Control (UICC). Lymph node dissections were performed on 6 patients and found no evidence of positive nodal disease. 7 patients received platinum-based adjuvant chemotherapy and experienced a median progression-free survival (PFS) of 37 months. Recurrent disease was varied in terms of locoregional versus distant spread, and these patients had largely suboptimal responses to salvage chemotherapy with doxorubicin, gemcitabine, and eribulin. Sites of metastatic disease included the liver, lungs, bone, and brain. While there is no consensus for the optimal treatment of this rare disease, MBTs seem to respond well to adjuvant platinum-taxane treatment after complete surgical resection, consistent with the current management approach of other epithelial ovarian cancers. Recurrent disease is considerably more difficult to manage, and clinicians may consider a wider avenue of treatment options to include hormonal, biologic, and radiation therapies.
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