Evidence map›Paper›PMID 30815502›Full record

ArticleOpen forum infectious diseases2019

Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study.

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Diabetes and gut microbiome.Frontiers in microbiology · 2024
    Review
  9. Article
  10. Article
  11. Picobirnaviruses encode proteins that are functional bacterial lysins.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ki Wook KimSchool of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Digby W AllenSchool of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Thomas BrieseCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York.
Jennifer J CouperAdelaide Medical School, Faculty and Health and Medical Sciences, University of Adelaide Robinson Research Institute, Australia.
Simon C BarryAdelaide Medical School, Faculty and Health and Medical Sciences, University of Adelaide Robinson Research Institute, Australia.
Peter G ColmanDepartment of Diabetes and Endocrinology, The Royal Melbourne Hospital Victoria, Australia.
Andrew M CotterillChildren's Health Queensland Hospital and Health Service, Australia.
Elizabeth A DavisTelethon Kids Institute, The University of Western Australia, Perth.
Lynne C GilesSchool of Public Health, University of Adelaide, Australia.
Leonard C HarrisonThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Mark HarrisChildren's Health Queensland Hospital and Health Service, Australia.
Aveni HaynesTelethon Kids Institute, The University of Western Australia, Perth.
Jessica L HortonSchool of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Sonia R IsaacsSchool of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Komal JainCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York.
Walter Ian LipkinCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York.
Grant MorahanCentre for Diabetes Research, The Harry Perkins Institute for Medical Research, Perth, Australia.
Claire MorbeyHunter Diabetes Centre, Newcastle, Australia.
Ignatius C N PangSchool of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, Australia.
Anthony T PapenfussThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Megan A S PennoAdelaide Medical School, Faculty and Health and Medical Sciences, University of Adelaide Robinson Research Institute, Australia.
Richard O SinnottDepartment of Computing and Information Systems, University of Melbourne, Australia.
Georgia SoldatosMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Rebecca L ThomsonAdelaide Medical School, Faculty and Health and Medical Sciences, University of Adelaide Robinson Research Institute, Australia.
Peter J VuillerminSchool of Medicine, Deakin University, Geelong, Australia.
John M WentworthThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Marc R WilkinsSchool of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, Australia.
William D RawlinsonSerology and Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia.
Maria E CraigSchool of Women's and Children's Health, University of New South Wales, Sydney, Australia.
ENDIA Study Group

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
NIAID NIH HHS U19 AI109761
6 · The paper itself

Abstract

backgroundThe importance of gut bacteria in human physiology, immune regulation, and disease pathogenesis is well established. In contrast, the composition and dynamics of the gut virome are largely unknown; particularly lacking are studies in pregnancy. We used comprehensive virome capture sequencing to characterize the gut virome of pregnant women with and without type 1 diabetes (T1D), longitudinally followed in the Environmental Determinants of Islet Autoimmunity study.

methodsIn total, 61 pregnant women (35 with T1D and 26 without) from Australia were examined. Nucleic acid was extracted from serial fecal specimens obtained at prenatal visits, and viral genomes were sequenced by virome capture enrichment. The frequency, richness, and abundance of viruses were compared between women with and without T1D.

resultsTwo viruses were more prevalent in pregnant women with T1D: picobirnaviruses (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.0-17.1;

conclusionsThese findings provide novel insight into the composition of the gut virome during pregnancy and demonstrate a distinct profile of viruses in women with T1D.

Indexed as

enteroviruspregnancytype 1 diabetesvirome capture sequencing

Identifiers

PMID30815502
PMCPMC6386807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.