Evidence map›Paper›PMID 30815470›Full record

ArticleERJ open research2019

Treatment response in COPD: does FEV

Konstantinos Kostikas, Timm Greulich, Alexander J Mackay, Nadine S Lossi, Maryam Aalamian-Mattheis, Xavier Nunez, Veronica A Pagano, Francesco Patalano, Andreas Clemens, Claus F Vogelmeier

Registry-linked trialAbstract read
In one paragraph

Article in ERJ open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06170125 (A Multicenter, Non-interventional, Observational Clinical Trial to Assess the Quality of Life in Patients With ChRonic ObstructIve Pulmonary Disease Who Require Tiotropium as additiOnal treatmeNt.), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06170125 unknown statusnot on this mapstarted 2024, after this paper: background citation

A Multicenter, Non-interventional, Observational Clinical Trial to Assess the Quality of Life in Patients With ChRonic ObstructIve Pulmonary Disease Who Require Tiotropium as additiOnal treatmeNt.

TypeobservationalSponsorElpen Pharmaceutical Co. Inc.Ran2024 to 2026Enrolled500ConditionsCOPDArmsTiotropium treated patients
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Real-Life Effectiveness of Aclidinium/Formoterol on COPD Control: The REDACT Observational Study.International journal of chronic obstructive pulmonary disease · 2026
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Future concepts in bronchodilation for COPD: dual-European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  13. FEVAmerican journal of respiratory and critical care medicine · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Patient-Reported Outcomes (PROs) in COPD Clinical Trials: Trends and Gaps.International journal of chronic obstructive pulmonary disease · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Konstantinos KostikasRespiratory Medicine Dept, University of Ioannina, Ioannina, Greece.
Timm GreulichDept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, Member of the German Center for Lung Research (DZL), Giessen, Germany.
Alexander J MackayAirways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Nadine S LossiNovartis Pharma GmbH, Nuremberg, Germany.
Maryam Aalamian-MattheisNovartis Pharma AG, Basel, Switzerland.
Xavier NunezTFS Develop, Barcelona, Spain.
Veronica A PaganoTFS Develop, Barcelona, Spain.
Francesco PatalanoNovartis Pharma AG, Basel, Switzerland.
Andreas ClemensNovartis Pharma AG, Basel, Switzerland.
Claus F VogelmeierDept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, Member of the German Center for Lung Research (DZL), Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between clinically relevant changes in patient-reported outcomes (PROs) and forced expiratory volume in 1 s (FEV

Identifiers

PMID30815470
PMCPMC6387992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.