Evidence map›Paper›PMID 30815375›Full record

ArticleWorld journal of clinical oncology2019

Impact of conditioning regimen on peripheral blood hematopoietic cell transplant.

Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi and 3 more

Open access · diamondAbstract read
In one paragraph

Article in World journal of clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Michael BurnsDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Anurag K SinghDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States. anurag.singh@roswellpark.org.
Carrie C HoeferDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Yali ZhangDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Paul K WallaceDepartment of Flow Cytometry, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
George L ChenDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Alexis PlatekDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Timothy B WinslowDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Austin J IovoliDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Christopher ChoiCenter for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Maureen RossDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Philip L McCarthyDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Theresa HahnDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, United States.
Roswell Park Comprehensive Cancer Center · US

Funding

RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
NCI NIH HHS P50 CA159981
6 · The paper itself

Abstract

aimTo investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/- total body irradiation (TBI) on outcomes after peripheral blood hematopoietic cell transplant (PBHCT).

methodsOur retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT and treated between 2001 and 2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank test.

resultsNeutrophil engraftment was significantly faster after reduced intensity TBI based conditioning [reduced intensity conditioning (RIC) + TBI] and > 4 × 10

conclusionTBI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PBHCT. Immune cell subsets may predict improved survival after unmanipulated PBHCT.

Indexed as

Graft-versus-host-diseaseNeutrophil engraftmentPeripheral blood hematopoietic cell transplantTotal body radiationTotal nucleated dose

Identifiers

PMID30815375
PMCPMC6390118
OpenAlexW2918137152

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.