Evidence map›Paper›PMID 30815364›Full record

ArticleJournal of clinical & translational endocrinology2019

The value of total thyroidectomy as the definitive treatment for Graves' disease: A single centre experience of 594 cases.

Calogero Cipolla, Giuseppa Graceffa, Sergio Calamia, Eugenio Fiorentino, Gianni Pantuso, Salvatore Vieni, Mario Latteri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & translational endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. The various faces of hyperthyroidism.Journal of clinical & translational endocrinology · 2020
    Article
  8. First tracheal ring fracture in a complex thyroid surgery.International journal of surgery case reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Calogero CipollaUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Giuseppa GraceffaUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Sergio CalamiaUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Eugenio FiorentinoUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Gianni PantusoUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Salvatore VieniUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
Mario LatteriUniversity of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThyroidectomy is the preferred approach as the definitive treatment for Graves' disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study.

methodsThe study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves' disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated.

resultsThe mean age of the patients was of 44.7 ± 12.7 years and 456 patients (76.7%) were females. The mean gland weight was 67.3 ± 10.8 g (range: 20-350 g) and, in 397 patients (66.8%), the gland weighed >40 g. The mean operative time was 125 ± 23.1 min (range: 65-212 min). Temporary and permanent hypocalcaemia developed in 241 (40.6%) and 3 patients (0.5%), respectively. Temporary and permanent recurrent laryngeal nerve palsy were recorded in 31 (5.2%) and 1 patients (0.16%) respectively. No patient developed a thyroid storm. On multivariate analysis, patient age ≤50 years (Odds ratio: 1; 95% Confidence Interval: 0.843-0.901) and thyroid weight >40 g (Odds ratio: 1; 95%, Confidence Interval: 0.852-0.974), were mainly associated with the occurrence of complications.

conclusionThis high-volume surgeon experience demonstrates that total thyroidectomy is a safe and effective treatment for Graves' disease. It is associated with a very low incidence rate of post-operative complications, most of which are transitory; therefore, it offers a rapid and definitive control of hyperthyroidism and its related symptoms.

Indexed as

ComplicationsGraves’ diseaseTotal thyroidectomy

Identifiers

PMID30815364
PMCPMC6377402
OpenAlexW2912169814

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.