ArticleChemistryOpen2019
Monitoring Hydrogenation Reactions using Benchtop 2D NMR with Extraordinary Sensitivity and Spectral Resolution.
Article in ChemistryOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- AutomatedAnalytical chemistry · 2026Article
- Hyphenation of 2D NMR With Hydrogenative PHIP.Magnetic resonance in chemistry : MRC · 2025Article
- Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application.Metabolites · 2023Review
- Deeper Insight into Photopolymerization: The Synergy of Time-Resolved Nonuniform Sampling and Diffusion NMR.Journal of the American Chemical Society · 2022Article
- Article
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- Photoreactivity of an Exemplary Anthracene Mixture Revealed by NMR Studies, including a Kinetic Approach.Molecules (Basel, Switzerland) · 2021Article
- Accelerating Restricted Diffusion NMR Studies with Time-Resolved and Ultrafast Methods.Analytical chemistry · 2020Article
- Enhancing Compression Level for More Efficient Compressed Sensing and Other Lessons from NMR Spectroscopy.Sensors (Basel, Switzerland) · 2020Article
- A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Monitoring Hydrogenation Reactions using Benchtop 2D NMR with Extraordinary Sensitivity and Spectral Resolution.ChemistryOpen · 2019Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-field benchtop nuclear magnetic resonance (BT-NMR) spectrometers with Halbach magnets are being increasingly used in science and industry as cost-efficient tools for the monitoring of chemical reactions, including hydrogenation. However, their use of low-field magnets limits both resolution and sensitivity. In this paper, we show that it is possible to alleviate these two problems through the combination of parahydrogen-induced polarization (PHIP) and fast correlation spectroscopy with time-resolved non-uniform sampling (TR-NUS). PHIP can enhance NMR signals so that substrates are easily detectable on BT-NMR spectrometers. The interleaved acquisition of one- and two-dimensional spectra with TR-NUS provides unique insight into the consecutive moments of hydrogenation reactions, with a spectral resolution unachievable in a standard approach. We illustrate the potential of the technique with two examples: the hydrogenation of ethylphenyl propiolate and the hydrogenation of a mixture of two substrates - ethylphenyl propiolate and ethyl 2-butynoate.
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