Evidence map›Paper›PMID 30815176›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2018

Using Demographic Factors and Comorbidities to Develop a Predictive Model for ICU Mortality in Patients with Acute Exacerbation COPD.

Sukrit S Jain, Indra Neil Sarkar, Paul C Stey, Rajsavi S Anand, Dustin R Biron, Elizabeth S Chen

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients.International journal of chronic obstructive pulmonary disease · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sukrit S JainAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.
Indra Neil SarkarAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.
Paul C SteyAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.
Rajsavi S AnandAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.
Dustin R BironAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.
Elizabeth S ChenAlpert Medical School and Center for Biomedical Informatics, Brown University, Providence, RI.

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2025
$45.0M
Leveraging the EHR to Collect and Analyze Social, Behavioral & Familial FactorsR01LM011364 · NLM · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHEN, ELIZABETH S., MELTON-MEAUX, GENEVIEVE B · 2012 to 2015
$1.4M
NIGMS NIH HHS U54 GM115677NLM NIH HHS R01 LM011364
6 · The paper itself

Abstract

Recognizing factors associated with mortality in patients admitted to the ICU with acute exacerbation of chronic obstructive pulmonary disease could reduce healthcare costs and improve end-of-life care. Previous studies have identified possible predictive variables, but analysis is lacking on the combined effect of demographic factors and comorbidities. Using the MIMIC-III database, this study examined factors associated with mortality in a model incorporating comorbidities, comorbidity indices, and demographic factors. After determining associations between predictive variables and mortality through univariate and multivariate binomial logistic regression, three predictive models were developed: (1) univariate GLM-derived logistic, (2) Mean Gini-derived logistic (MGDL), and (3) random forest. The MGDL model best predicted mortality with an AUROC of 0.778. Variables with the greatest relative importance in determining mortality included the Charlson Comorbidity Index, Elixhauser Index, male, and arrhythmia. The results support the potential of using the MGDL model and need for further work in exploring demographic factors.

Indexed as

ComorbidityHospital MortalityIntensive Care UnitsAdultAgedAged, 80 and overFemaleHumansLogistic ModelsMachine LearningMaleMiddle AgedPrognosisPulmonary Disease, Chronic ObstructiveROC CurveSocioeconomic Factors

Identifiers

PMID30815176
PMCPMC6371239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.