Evidence map›Paper›PMID 30815161›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2018

Identifying Similar Non-Lattice Subgraphs in Gene Ontology based on Structural Isomorphism and Semantic Similarity of Concept Labels.

Rashmie Abeysinghe, Xufeng Qu, Licong Cui

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A review of auditing techniques for the Unified Medical Language System.Journal of the American Medical Informatics Association : JAMIA · 2020
    Review
  3. Leveraging Non-lattice Subgraphs to Audit Hierarchical Relations in NCI Thesaurus.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019
    Article
4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Rashmie AbeysingheDepartment of Computer Science, University of Kentucky, Lexington, KY.
Xufeng QuDepartment of Computer Science, University of Kentucky, Lexington, KY.
Licong CuiDepartment of Computer Science, University of Kentucky, Lexington, KY.

Funding

An Ontology-driven Faceted Query Engine for the Kentucky Cancer RegistryR21CA231904 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CUI, LICONG, ZHANG, GUO-QIANG · 2018 to 2019
$350k
NCI NIH HHS R21 CA231904
6 · The paper itself

Abstract

Non-Lattice Subgraphs (NLSs) are graph fragments of a terminology which violates the lattice property, a desirable property for a well-formed terminology. They have been proven to be useful in identifying inconsistencies in biomed-ical terminologies. Similar NLSs may denote similar inconsistencies that may suggest possibly similar remediations. Therefore, we investigate a structural-semantic-based approach to identify similar NLSs in the Gene Ontology (GO). For an input NLS, we first obtain all its isomorphic NLSs. Then, we compare each concept of the input NLS with the corresponding concept in an isomorphic NLS and then compute a similarity score for the two NLSs. Applying this approach to 10 different structures of NLSs in GO, we found that 38.43% (910/2368) of NLSs have at least one similar NLS. We also observed some interesting lexical patterns frequently existing in similar NLSs. Our approach may be applicable to other biomedical terminologies for identifying similar NLSs.

Indexed as

Gene OntologySemantics

Identifiers

PMID30815161
PMCPMC6371383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.