Evidence map›Paper›PMID 30815153›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2018

Combine Factual Medical Knowledge and Distributed Word Representation to Improve Clinical Named Entity Recognition.

Yonghui Wu, Xi Yang, Jiang Bian, Yi Guo, Hua Xu, William Hogan

Open access · greenAbstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  4. TAX-Corpus: Taxonomy based Annotations for Colonoscopy Evaluation.Biomedical engineering systems and technologies, international joint conference, BIOSTEC ... revised selected papers. BIOSTEC (Conference) · 2022
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  5. The h-ANN Model: Comprehensive Colonoscopy Concept Compilation Using Combined Contextual Embeddings.Biomedical engineering systems and technologies, international joint conference, BIOSTEC ... revised selected papers. BIOSTEC (Conference) · 2022
    Article
  6. Leveraging Semantic Type Dependencies for Clinical Named Entity Recognition.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Clinical concept extraction using transformers.Journal of the American Medical Informatics Association : JAMIA · 2020
    Article
  11. Article
  12. Deep learning in clinical natural language processing: a methodical review.Journal of the American Medical Informatics Association : JAMIA · 2020
    Review
  13. Article
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  16. Article
  17. A Study of Deep Learning Methods for De-identification of Clinical Notes at Cross Institute Settings.Proceedings. IEEE International Conference on Healthcare Informatics · 2019
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yonghui WuDepartments of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Xi YangDepartments of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Jiang BianDepartments of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Yi GuoDepartments of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Hua XuSchool of Biomedical Informatics, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
William HoganDepartments of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
The University of Texas Health Science Center at Houston · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Advancing Cancer Pharmacoepidemiology Research Through EHRs and InformaticsU24CA194215 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TAO, CUI, YANG, PING · 2016 to 2020
$3.3M
Real-time Disambiguation of Abbreviations in Clinical NotesR01LM010681 · NLM · VANDERBILT UNIVERSITY · PI XU, HUA · 2010 to 2017
$3.1M
NCATS NIH HHS UL1 TR001427NCI NIH HHS U24 CA194215NLM NIH HHS R01 LM010681
6 · The paper itself

Abstract

There has been an increasing interest in developing deep learning methods to recognize clinical concepts from narrative clinical text. Recently, several studies have reported that Recurrent Neural Networks (RNNs) outperformed traditional machine learning methods such as Conditional Random Fields (CRFs). Deep learning-based Named Entity Recognition (NER) systems often use statistical language models to learn word embeddings from unlabeled corpora. However, current word embedding methods have limitations to learn decent representations for low-frequency words. Medicine is a knowledge-extensive domain; existing medical knowledge has the potential to improve feature representations for less frequent yet important words. However, it is still not clear how existing medical knowledge can help deep learning models in clinical NER tasks. In this study, we integrated medical knowledge from the Unified Medical Language System with word embeddings trained from an unlabeled clinical corpus in RNNs for detection of problems, treatments and lab tests. We examined three different ways to generate medical knowledge features, including a dictionary lookup program, the KnowledgeMap system, and the MedLEE system. We also compared representing medical knowledge as one-hot vectors versus representing medical knowledge as embedding layers. The evaluation results showed that the RNN with medical knowledge as embedding layers achieved new state-of-the-art performance (a strict F1 score of 86.21% and a relaxed F1 score of 92.80%) on the 2010 i2b2 corpus, outperforming an RNN with only word embeddings and RNNs with medical knowledge as one-hot vectors. This study demonstrated an efficient way of integrating medical knowledge with distributed word representations for clinical NER.

Indexed as

Deep LearningNeural Networks, ComputerHumansNatural Language ProcessingUnified Medical Language System

Identifiers

PMID30815153
PMCPMC6371322
OpenAlexW2940685834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.