ReviewFrontiers in plant science2019
Hemerythrin E3 Ubiquitin Ligases as Negative Regulators of Iron Homeostasis in Plants.
Review in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Comparative transcriptome and physiological analyses unveil differential responses ofFrontiers in plant science · 2026Article
- Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins.Nature communications · 2025Article
- Genome-wide analysis of CHYR gene family and BnA03.CHYR.1 functional verification under salt stress in Brassica napus L.BMC plant biology · 2025Article
- Combating plant diseases through transition metal allocation.The New phytologist · 2025Review
- Article
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Genetic basis of the historical iron-accumulating dgl and brz mutants in pea.The Plant journal : for cell and molecular biology · 2024Article
- The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification of quantitative trait loci and candidate genes for seed folate content in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The Molecular Mechanism ofPlants (Basel, Switzerland) · 2023Article
- Iron Nutrition in Plants: Towards a New Paradigm?Plants (Basel, Switzerland) · 2023Review
- Comprehensive Survey of ChIP-Seq Datasets to Identify Candidate Iron Homeostasis Genes Regulated by Chromatin Modifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Coupling VIGS with Short- and Long-Term Stress Exposure to Understand the Fiskeby III Iron Deficiency Stress Response.International journal of molecular sciences · 2022Article
- Genome-wide analysis and functional characterization of CHYR gene family associated with abiotic stress tolerance in bread wheat (Triticum aestivum L.).BMC plant biology · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- Micronutrient homeostasis in plants for more sustainable agriculture and healthier human nutrition.Journal of experimental botany · 2022Review
- Iron in leaves: chemical forms, signalling, and in-cell distribution.Journal of experimental botany · 2022Review
- A tale of two metals: Biofortification of rice grains with iron and zinc.Frontiers in plant science · 2022Review
- Genome-Wide Identification, Characterization and Expression Analysis of SoybeanInternational journal of molecular sciences · 2021Article
- Diversity of structures and functions of oxo-bridged non-heme diiron proteins.Archives of biochemistry and biophysics · 2021Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) is an essential nutrient for plants, but at the same time its redox properties can make it a dangerous toxin inside living cells. Homeostasis between uptake, use and storage of Fe must be maintained at all times. A small family of unique hemerythrin E3 ubiquitin ligases found in green algae and plants play an important role in avoiding toxic Fe overload, acting as negative regulators of Fe homeostasis. Protein interaction data showed that they target specific transcription factors for degradation by the 26S proteasome. It is thought that the activity of the E3 ubiquitin ligases is controlled by Fe binding to the N-terminal hemerythrin motifs. Here, we discuss what we have learned so far from studies on the HRZ (Hemerythrin RING Zinc finger) proteins in rice, the homologous BTS (BRUTUS) and root-specific BTSL (BRUTUS-LIKE) in Arabidopsis. A mechanistic model is proposed to help focus future research questions towards a full understanding of the regulatory role of these proteins in Fe homeostasis in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.