ReviewFrontiers in pharmacology2019
Nocebo Effects and Negative Suggestions in Daily Clinical Practice - Forms, Impact and Approaches to Avoid Them.
Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- Trial
- Impact of Verbal Suggestions on Finger Flexor Activation and Strength in Healthy Individuals.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial.BMJ (Clinical research ed.) · 2020Trial
- Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled Study on Acupuncture in Integrative Cancer Care.Integrative cancer therapiesTrial
- Prehabilitation for Limb Salvage Surgery: A Practical and Evidence-based Guide.Plastic and reconstructive surgery. Global open · 2026Article
- MyCODE: a prospective evaluation of lay-language molecular tumor board protocols in precision oncology.The oncologist · 2026Article
- Comfort-based Pain Management for Intralesional Treatment of Pediatric Post-otoplasty Keloids.Acta dermato-venereologica · 2026Article
- Understanding and leveraging placebo and nocebo effects in perioperative care: a cross-sectional survey of German-speaking anesthesiologists.BMC anesthesiology · 2026Observational
- Operating Room Professionals' Awareness of Possible Unconscious Auditory Perception During General Anesthesia: A Cross-Sectional Survey Study.Anesthesiology research and practice · 2026Article
- [Words like medicine-Therapeutic communication in anesthesia].Die Anaesthesiologie · 2025Review
- Tensions of Low-Back Pain and Lifting; Bridging Clinical Low-Back Pain and Occupational Lifting Guidelines.Journal of occupational rehabilitation · 2024Article
- Risk factors associated with nocebo effects: A review of reviews.Brain, behavior, & immunity - health · 2024Review
- The Experimental Pain Experienced in a Cold Pressor Task Is Influenced by Hemoglobin Levels in Young Adult Females.Cureus · 2024Article
- Medicine plus mindset: A mixed-methods evaluation of a novel mindset-focused training for primary care teams.Patient education and counseling · 2024Article
- Clinical experience with medical hypnosis as an adjunctive therapy in heart surgery.Frontiers in psychology · 2024Article
- Hypnosis in psychotherapy, psychosomatics and medicine. A brief overview.Frontiers in psychology · 2024Review
- Touching the unconscious in the unconscious - hypnotic communication with unconscious patients.Frontiers in psychology · 2024Review
- Communication in the ICU: An Unintended Nocebo Effect?Journal of patient experience · 2024Article
- Does Educational Status Influence Parents' Response to Bad News in the NICU?Children (Basel, Switzerland) · 2023Article
- [What's new … Patients are listening-communication under general anesthesia].Die Anaesthesiologie · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medical situations are hot spots in the life of a patient with potentially long lasting effects arising from the use of either negative expressions or encouraging statements, or the lack of empathy or a positive physician-patient relationship. Health care personnel should be aware of and evaluate what patients are exposed to, hear and see. Knowing more about the effects of nocebos and negative suggestions, combined with increased attention to these matters, provides the basis for better recognition of detrimental influences in their own clinical environment and to be able to avoid, stop or neutralize them. After anamnesis patients should not be left with a focus on a negative past, but shifted to positive experiences prior to their illness, or to positive expectations in the future following surgery and rehabilitation. For example, after examining an injured leg the doctor should not turn to the computer for documentation unless he has shifted the patient's focus on the other, unimpaired leg. "Is that painful too? No? Good! Can you feel that? Yes? Perfect! Can you bend that knee, move these toes? Great! That's good." This example draws attention to the fact that negative effects (discussed in the following) substantially are dependent on the focus of the patient and thus can be affected by focus shift and distraction. Patients, their symptoms and their healing are negatively affected by the omission of placebo effects, by nocebo effects and by negative suggestions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.