ReviewFrontiers in neuroanatomy2019
Extreme Neuroplasticity of Hippocampal CA1 Pyramidal Neurons in Hibernating Mammalian Species.
Review in Frontiers in neuroanatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effects of natural deep hypothermia on cognitive abilities in mammals: hibernators and neonates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Review
- Review
- Melatonin Supplementation in Alzheimer's disease: The Potential Role in Neurogenesis.Molecular neurobiology · 2025Review
- Aberrant neuronal firing: a paracrine route to glioblastoma expansion.Cell communication and signaling : CCS · 2025Article
- Melatonin: A potential nighttime guardian against Alzheimer's.Molecular psychiatry · 2025Review
- Review
- Linking Hypothermia and Altered Metabolism with TrkB Activation.ACS chemical neuroscience · 2023Article
- Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Seasonal variations of serotonin in the visual system of an ant revealed by immunofluorescence and a machine learning approach.Royal Society open science · 2022Article
- Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.Molecular cell · 2021Article
- Cytoskeletal Arrest: An Anoxia Tolerance Mechanism.Metabolites · 2021Review
- Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease.Scientific reports · 2021Article
- TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.Life science alliance · 2021Article
- Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation.Cerebral cortex communications · 2020Article
- Calcium-Binding Proteins in the Nervous System during Hibernation: Neuroprotective Strategies in Hypometabolic Conditions?International journal of molecular sciences · 2019Review
- Neuronal Activity in the Hibernating Brain.Frontiers in neuroanatomy · 2019Article
- Daily Torpor and Sleep in a Non-human Primate, the Gray Mouse Lemur (Frontiers in neuroanatomy · 2019Article
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Authors and funding
2 authors.
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Abstract
In awake and behaving mammals (with core and brain temperatures at ~37°C), hippocampal neurons have anatomical and physiological properties that support formation of memories. However, studies of hibernating mammalian species suggest that as hippocampal temperature falls to values below ~10°C, CA1 neurons lose their ability to generate long term potentiation (LTP), a basic form of neuroplasticity. That is, the persistent increase in CA3-CA1 synaptic strength following high-frequency stimulation of CA3 fibers (the hallmark of LTP generation at 37°C) is no longer observed at low brain temperatures although the neurons retain their ability to generate action potentials. In this review, we examine the relationship of LTP to recently observed CA1 structural changes in pyramidal neurons during the hibernation cycle, including the reversible formation of hyperphosphorylated tau. While CA1 neurons appear to be stripped of their ability to generate LTP at low temperatures, their ability to still generate action potentials is consistent with the longstanding proposal that they have projections to neural circuits controlling arousal state throughout the hibernation cycle. Recent anatomical studies significantly refine and extend previous studies of cellular plasticity and arousal state and suggest experiments that further delineate the mechanisms underlying the extreme plasticity of these CA1 neurons.
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