ArticleFrontiers in neuroscience2019
HbA1C Variability Is Strongly Associated With the Severity of Peripheral Neuropathy in Patients With Type 2 Diabetes.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy.Diabetes, obesity & metabolism · 2026Pooled it
- A systematic review of randomized controlled trials of the Wenyang Huoxue method in treating diabetic peripheral neuropathy.Medicine · 2019Pooled it
- Analyzing longitudinal antidiabetic medication patterns: a data-driven clustering framework.BMC medical informatics and decision making · 2026Article
- Quantitative ultrasound assessment of lower limb muscle morphology in type 2 diabetes with and without peripheral neuropathy.F1000Research · 2026Article
- Impact of HbA1c variability and time-in-range fluctuations on large and small nerve fiber dysfunction in well-controlled type 2 diabetes: A prospective cohort observational study.Journal of diabetes investigation · 2025Observational
- Relationship between nerve ultrasonography image and electrophysiology in diabetic polyneuropathy.Journal of diabetes investigation · 2025Article
- Nerve Conduction Study, Sympathetic Skin Response Test, and Demographic Correlates in Type 2 Diabetes Mellitus Patients.Annals of rehabilitation medicine · 2025Article
- Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy.Nature communications · 2024Article
- Nerve conduction velocity studies in diabetic peripheral neuropathy involving sural nerve-A meta-analysis.Journal of family medicine and primary care · 2024Article
- Glycemic variability's impact on painful diabetic peripheral neuropathy in type 2 diabetes patients.Scientific reports · 2024Article
- Dietary phytochemical index and its relationship with diabetic sensorimotor polyneuropathy: a case-control study.Scientific reports · 2024Article
- The Association between the Severity of Distal Sensorimotor Polyneuropathy and Increased Carotid Atherosclerosis in Individuals with Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2024Article
- Prognostic value of longitudinal HbA1c variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study.Journal of diabetes investigation · 2024Observational
- Multifractal Heart Rate Value Analysis: A Novel Approach for Diabetic Neuropathy Diagnosis.Healthcare (Basel, Switzerland) · 2024Article
- Association of Hematological Parameters and Diabetic Neuropathy: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Unilateral Phrenic Nerve Palsy as a Presentation of Diabetes Mellitus: A Rare Case Report.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- Quantitative thermal testing as a screening and follow-up tool for diabetic sensorimotor polyneuropathy in patients with type 2 diabetes and prediabetes.Frontiers in neuroscience · 2023Article
- Correlation Between Glycemic Variability and Diabetic Complications: A Narrative Review.International journal of general medicine · 2023Review
- The Effects of Indoxyl Sulfate and Oxidative Stress on the Severity of Peripheral Nerve Dysfunction in Patients with Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2022Article
- The Association Between Sustained HbA1c Control and Long-Term Complications Among Individuals with Type 2 Diabetes: A Retrospective Study.Advances in therapy · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variability in HbA1c is associated with a higher risk of cardiovascular disease and microvascular complications in patients with type 2 diabetes. The present study evaluated the severity of somatic nerve dysfunction at different stages of chronic glycemic impairment, and its correlation with different cardio-metabolic parameters. The study was conducted on 223 patients with type 2 diabetes. We calculated the intrapersonal mean, standard deviation (SD), and coefficient of variation of HbA1c for each patient using all measurements obtained for 3 years prior to the study. Patients were divided into quartiles according to the SD of HbA1c, and we constructed composite scores of nerve conduction as the severity of peripheral neuropathy. Linear regression analysis was performed to evaluate the influence of independent variables on mean composite scores. Those with higher SD-HbA1c had a higher body mass index, mean and index HbA1c, triglyceride and uric acid level, urinary albumin excretion and albumin-creatinine ratio, proportion of insulin therapy, and prevalence of hypertension as the underlying diseases, but lower estimate glomerular filtration rate (eGFR). In addition, those with higher SD-HbA1c showed lower amplitudes and reduced motor nerve conduction velocity in tested nerves, and lower sensory nerve conduction velocity in the sural nerve. Furthermore, those with higher SD-HbA1c had higher composite scores of low extremities. Multiple linear regression analysis revealed that diabetes duration, SD-HbA1c, and eGFR were independently associated with mean composite scores. Based on our results, HbA1c variability plus chronic glycemic impairment is strongly associated with the severity of peripheral neuropathy in patients with type 2 diabetes. Aggressively control blood glucose to an acceptable range and avoid blood glucose fluctuations by individualized treatment to prevent further nerve damage.
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