ArticleJournal of global infectious diseases
Clinico-epidemiological Study of Viral Acute Encephalitis Syndrome Cases and Comparison to Nonviral Cases in Children from Eastern India.
Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Pentoxifylline in children with acute encephalitis syndrome: a randomized control trial.European journal of pediatrics · 2026Trial
- Etiological spectrum, risk factors, and outcomes of pediatric acute encephalitis: a 17-year pediatric intensive care unit retrospective cohort study.BMC pediatrics · 2026Article
- Changes in etiology, diagnostic challenges, and prognostic factors in pediatric acute encephalitis: Insights from an 18-year retrospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Etiology of Acute Encephalitis Syndrome in Adults in a Tertiary Care Center in Eastern Uttar Pradesh.The American journal of tropical medicine and hygiene · 2025Article
- Article
- Investigation of acute encephalitis syndrome with implementation of metagenomic next generation sequencing in Nepal.BMC infectious diseases · 2024Article
- The Worldwide Prevalence of Herpes Simplex Virus Encephalitis and Meningitis: A Systematic Review and Meta-Analysis.Turkish archives of pediatrics · 2023Article
- Diagnosis of Indigenous Non-Malarial Vector-Borne Infections from Malaria Negative Samples from Community and Rural Hospital Surveillance in Dhalai District, Tripura, North-East India.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical Feature and Outcome of Childhood Status Epilepticus in a Teaching Hospital, Odisha, India.Cureus · 2020Article
- Profile of Acute Encephalitis Syndrome Patients from South India.Journal of global infectious diseasesArticle
- A spectrum of viral diseases in Odisha state, eastern India: An evidence-based analysis from 2010-2017.Journal of postgraduate medicineArticle
- Validation of the Scrub Typhus Encephalitis Assessment Tool for the Management of Acute Encephalitis Syndrome.Journal of global infectious diseasesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective is to study the clinico-epidemiological features of viral acute encephalitis syndrome (AES) cases and compare them with nonviral AES cases in children from Eastern India.
methodsThis prospective observational study was conducted in the department of pediatrics of a tertiary care teaching hospital in Eastern India over 18-month period. Children (6 months to 15 years) with acute onset of fever (≥37.5°C) and a change in mental status (including symptoms such as confusion, disorientation, coma, or inability to talk) and/or new onset of seizures (excluding simple febrile seizures) were included in the study. The main outcome measures were the etiology and proportion attributed to viruses causing AES with clinical correlation.
resultsOf 834 of clinically suspected AES cases, viral etiology could be confirmed in 136 (16.3%) cases (herpes simplex virus-1 [HSV-I] was most common). The 5-15 years' age group was most commonly affected (boys > girls). More cases occurred from July to November. The presence of rash and Glasgow Coma Scale <8 at admission was significantly higher in viral AES. During hospitalization, development of shock, ventilatory requirement, duration of stay, and mortality was significantly higher in viral AES. On neuroimaging, global cerebral injury was common in HSV, Japanese encephalitis, and varicella-virus AES.
conclusionsViral etiology forms a significant proportion of pediatric AES. Morbidity and mortality are high in viral compared to nonviral AES. Herpes encephalitis (HSV-I) is the most common cause of pediatric AES in Eastern India. Viral AES has poor prognosis compared to nonviral AES.
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