ArticleNature2019
A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.
- "Quiescence" in the resting zone of the growth plate: a systematic review.Stem cells (Dayton, Ohio) · 2026Pooled it
- Decoding growth hormone actions on human growth plate stem cells.Trends in endocrinology and metabolism: TEM · 2026Article
- Mechanical Loading Prevents Bone Growth Impairment in TNF-Overexpressing Mice with Chronic Inflammation.Cells · 2026Article
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- Human growth plates house resting zone sub-populations with features of quiescent stem cells.Bone research · 2026Article
- miR-433 targets BMP and Indian hedgehog signaling to coordinate murine postnatal growth plate dynamics.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Growth Plate Injuries: Advances and Future Directions in Regenerative Medicine.Annals of biomedical engineering · 2026Review
- Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026Review
- Bone marrow endosteum houses Hedgehog-susceptible Dlx5-expressing osteoblast precursor cells.Communications biology · 2026Article
- Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling.Nature communications · 2026Article
- Fibrous-layer resident Angptl7Cell research · 2026Article
- Emerging molecular mechanisms of the ECM-exosome growth-plate axis in idiopathic short stature.Frontiers in cell and developmental biology · 2026Review
- Growth hormone regulates the stem cell population in the growth plate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb.Nature communications · 2025Article
- Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration.Science signaling · 2025Article
- A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Growth Plate Skeletal Stem Cells and Their Actions Within the Stem Cell Niche.International journal of molecular sciences · 2025Review
- Stem Cell Niche Concept: Search for Current Expert Consensus.International journal of molecular sciences · 2025Review
- Skeletal stem cells, a new direction for the treatment of bone and joint diseases.World journal of orthopedics · 2025Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 7 institutions in 5 countries.
Phillip T NewtonDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. phillip.newton@ki.se.
Lei LiDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Baoyi ZhouDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Christoph SchweingruberDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Maria HovorakovaDepartment of Developmental Biology, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.
Meng XieDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Xiaoyan SunDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.
Lakshmi SandhowCenter for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden.
Artem V ArtemovDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Evgeny IvashkinDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Simon SuterDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Vyacheslav DyachukDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Maha El ShahawyDepartment of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Amel Gritli-LindeDepartment of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Thibault BouderliqueDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Julian PetersenDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Annelie MollbrinkScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Joakim LundebergScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Grigori EnikolopovCenter for Developmental Genetics and Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA.
Hong QianCenter for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden.
Kaj FriedDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Maria KasperDepartment of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.
Eva HedlundDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Igor AdameykoDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Lars SävendahlDepartment of Women's and Children's Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden.
Andrei S ChaginDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. andrei.chagin@ki.se.
Karolinska Institutet · SEKTH Royal Institute of Technology · SEUniversity of Gothenburg · SEA.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences · RUCzech Academy of Sciences, Institute of Experimental Medicine · CZSechenov University · RUStony Brook University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Longitudinal bone growth in children is sustained by growth plates, narrow discs of cartilage that provide a continuous supply of chondrocytes for endochondral ossification
Indexed as
AgingAnimalsCartilageCell Self RenewalChondrocytesClone CellsFemaleGrowth PlateMaleMechanistic Target of Rapamycin Complex 1MiceStem Cell NicheMechanistic Target of Rapamycin Complex 1
Identifiers
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Textmetadata
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.