Evidence map›Paper›PMID 30814734›Full record

ArticleNature2019

Structural basis for KCTD-mediated rapid desensitization of GABA

Sanduo Zheng, Nohely Abreu, Joshua Levitz, Andrew C Kruse

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. GABAFrontiers in pharmacology · 2026
    Review
  6. KCTD Family: Emerging Regulators of GPCR Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sanduo ZhengDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Nohely AbreuDepartment of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
Joshua LevitzDepartment of Biochemistry, Weill Cornell Medicine, New York, NY, USA.
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. andrew_kruse@hms.harvard.edu.
Cornell University · USBoston VA Research Institute · USHarvard University · US

Funding

Molecular Mechanisms of Synaptic G Protein-Coupled ReceptorsR35GM124731 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITZ, JOSHUA · 2017 to 2021
$2.1M
NIGMS NIH HHS R35 GM124731
6 · The paper itself

Abstract

The GABA

Indexed as

Signal TransductionCrystallography, X-RayG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsHumansIntracellular Signaling Peptides and ProteinsMicroscopy, ElectronModels, BiologicalModels, MolecularNerve Tissue ProteinsProtein BindingProtein DomainsProteinsReceptors, GABA-BG-protein Beta gammaG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsIntracellular Signaling Peptides and ProteinsKCTD12 protein, humanKCTD16 protein, humanKCTD8 protein, humanNerve Tissue ProteinsProteinsReceptors, GABA-B

Identifiers

PMID30814734
PMCPMC6405316
OpenAlexW2917299118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.