ArticleNature2019
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers.
0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed
19.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
348 citing papers in PubMed, 511 citations in OpenAlex.
- Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+CD8+ T cells.The Journal of clinical investigation · 2024Trial
- Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Trial
- Single-cell gene regulatory networks characterize colonic stem and immune cell homeostasis iniScience · 2026Article
- CRISPRa screen unveils noncanonical NF-κB to boost the antitumor activity of TCR-based CAR-T cells.Cellular & molecular immunology · 2026Article
- T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis.Angiogenesis · 2026Article
- Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of novel paracrine therapeutic targets in peritoneal metastases through integrative proteotranscriptomic analysis of ascites.Molecular cancer · 2026Article
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- Data-driven identification of cell subtypes for single-cell transcriptomic data with Subtypist.Briefings in bioinformatics · 2026Article
- Adoptive cell therapy in lung cancer: progress, challenges, and prospects.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Article
- Targeting NR4A1 (Nur77) in Macrophage Polarization: Molecular Mechanisms and Translational Prospects for Cardiac Repair After Myocardial Infarction.International journal of molecular sciences · 2026Review
- Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes.Nucleic acids research · 2026Article
- Single-cell and spatial transcriptomic profiling reveals distinct immune landscapes in murine lungs infected with H1N1 versus H5N1 influenza viruses.Journal of virology · 2026Article
- Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.Nature communications · 2026Article
- Transcription factors remodel tumor immune microenvironment by impacting multiple immune cells.Discover oncology · 2026Review
- SIRPγ limits effector differentiation of human CD8 T cells in response to subthreshold TCR-signaling.ImmunoHorizons · 2026Article
- Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- T Cell Exhaustion as a Regulated Differentiation Programme.European journal of immunology · 2026Review
288 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 8 institutions in 2 countries.
Xindong LiuInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. xindongliu@hotmail.com.
Yun WangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Huiping LuTsinghua University, Beijing, China.
Jing LiTsinghua University, Beijing, China.
Xiaowei YanInstitute for Systems Biology, Seattle, WA, USA.
Minglu XiaoInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, China.
Jing HaoTsinghua University, Beijing, China.
Andrei AlekseevMD Anderson Cancer Center, Houston, TX, USA.
Hiep KhongMD Anderson Cancer Center, Houston, TX, USA.
Tenghui ChenMD Anderson Cancer Center, Houston, TX, USA.
Rui HuangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Jin WuInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Qiwen ZhaoInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Qi WuTsinghua University, Beijing, China.
Senlin XuInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Xiaohu WangTsinghua University, Beijing, China.
Wei JinTsinghua University, Beijing, China.
Shicang YuInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Yan WangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Lai WeiZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Aibo WangMD Anderson Cancer Center, Houston, TX, USA.
Bo ZhongMedical Research Institute, School of Medicine, Wuhan University, Wuhan, China.
Ling NiTsinghua University, Beijing, China.
Xiaolong LiuShanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Roza NurievaMD Anderson Cancer Center, Houston, TX, USA.
Lilin YeInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, China.
Qiang TianInstitute for Systems Biology, Seattle, WA, USA.
Xiu-Wu BianInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. bianxiuwu@263.net.
Chen DongTsinghua University, Beijing, China. chendong@tsinghua.edu.cn.
Tsinghua University · CNArmy Medical University · CNThe University of Texas MD Anderson Cancer Center · USSouthwest Hospital · CNChinese Academy of Sciences · CNInstitute for Systems Biology · USSun Yat-sen University · CNWuhan University · CN
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MRole of Cul4A in Governing Th2-Type ToleranceR01HL143520 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2018 to 2021
$1.6MSTAT1: New regulator of inflammatory Th17 and Th2 cellsR21AI120012 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2016 to 2017
$440kRole of Cul4A in Th2 tolerance and airway inflammationR56AI125269 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2017 to 2017
$300kGrail-targeting breaks the immune tolerance to melanomaR03CA219760 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NURIEVA, ROZA INSAFETDINOVNA · 2017 to 2018
$160kNCI NIH HHS P30 CA016672NCI NIH HHS R03 CA219760NHLBI NIH HHS R01 HL143520NIAID NIH HHS R21 AI120012NIAID NIH HHS R56 AI125269
Abstract
T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment
Indexed as
GenomeAcetylationAnimalsArenaviridae InfectionsCell Line, TumorColitisEpigenesis, GeneticFemaleGene Expression RegulationHistonesImmune ToleranceImmunotherapyLymphocytic choriomeningitis virusMiceMice, Inbred C57BLNeoplasmsHistonesNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Transcription Factor AP-1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.