Evidence map›Paper›PMID 30814660›Full record

ArticleScientific reports2019

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma.

Jeroen Verhoeven, Fabian Hulpia, Ken Kersemans, Julie Bolcaen, Stef De Lombaerde, Jan Goeman, Benedicte Descamps, Giorgio Hallaert, Caroline Van den Broecke, Karel Deblaere and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. CD98 Light Chain LAT1 Tracers in PET-CT Diagnosis of Cancer Patients.Anti-cancer agents in medicinal chemistry · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Radiosynthesis and Preclinical Evaluation ofMolecular pharmaceutics · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Intra-individual dynamic comparison ofScientific reports · 2020
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Technical feasibility of [Radiation oncology (London, England) · 2019
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jeroen VerhoevenLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium. Jeroen.Verhoeven@ugent.be.ORCID 0000-0002-6641-7760
Fabian HulpiaLaboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium.
Ken KersemansGhent University Hospital, Department of Nuclear Medicine, Ghent, Belgium.
Julie BolcaenGhent University Hospital, Department of Nuclear Medicine, Ghent, Belgium.
Stef De LombaerdeLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Jan GoemanLaboratory for Organic and Bio-organic synthesis, Ghent University, Ghent, Belgium.
Benedicte DescampsIBiTech-MEDISIP Ghent University, Department of Electronics and Information Systems, Ghent, Belgium.ORCID 0000-0001-8879-1772
Giorgio HallaertGhent University Hospital, Department of Neurosurgery, Ghent, Belgium.
Caroline Van den BroeckeGhent University Hospital, Department of Pathology, Ghent, Belgium.
Karel DeblaereGhent University Hospital, Department of Radiology and Medical Imaging, Ghent, Belgium.
Christian VanhoveIBiTech-MEDISIP Ghent University, Department of Electronics and Information Systems, Ghent, Belgium.
Johan Van der EyckenLaboratory for Organic and Bio-organic synthesis, Ghent University, Ghent, Belgium.
Serge Van CalenberghLaboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium.ORCID 0000-0002-4201-1264
Ingeborg GoethalsGhent University Hospital, Department of Nuclear Medicine, Ghent, Belgium.
Filip De VosLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Ghent University Hospital · BEGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of O-(2-[

Indexed as

AnimalsApoptosisCell ProliferationFemaleGlioblastomaHumansLarge Neutral Amino Acid-Transporter 1Positron-Emission TomographyRadiopharmaceuticalsRatsTumor Cells, CulturedTyrosineXenograft Model Antitumor Assays(18F)fluoroethyltyrosineLarge Neutral Amino Acid-Transporter 1RadiopharmaceuticalsSLC7A5 protein, humanTyrosine

Identifiers

PMID30814660
PMCPMC6393465
OpenAlexW2917076396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.