ArticleScientific reports2019
Discordant attributes of structural and functional brain connectivity in a two-layer multiplex network.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
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- Multimodal brain network disruption and structural-functional decoupling in overt hypothyroidism.Frontiers in endocrinology · 2026Article
- Local brain connectome parameters across the spectrum of clinical cognitive decline.Frontiers in neuroscience · 2026Article
- Optimal structure of signal networks for efficient information aggregation.Scientific reports · 2025Article
- Musicians' brains at rest: multilayer network analysis of magnetoencephalography data.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Abnormal alterations in structure-function coupling at the modular level in patients with postherpetic neuralgia.Scientific reports · 2025Article
- Network topology and cannabis use following two weeks of monitored abstinence: moderation of sex and patterns of use findings.Frontiers in adolescent medicine · 2025Article
- Audiovisual integration and whole-brain networks in preterm and full-term neonates: A two-layer multiplex network perspective on structural and functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Reorganization of brain connectivity across the spectrum of clinical cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Inhibition of the inferior parietal lobe triggers state-dependent network adaptations.Heliyon · 2024Article
- The brain's first "traffic map" through Unified Structural and Functional Connectivity (USFC) modeling.Communications biology · 2024Article
- Structural and functional connectivity associations with anterior cingulate sulcal variability.Brain structure & function · 2024Article
- Topological alterations in white matter anatomical networks in cervical dystonia.BMC neurology · 2024Article
- The Brain's First "Traffic Map" through Unified Structural and Functional Connectivity (USFC) Modeling.Research square · 2024Article
- Structural and functional connectivity associations with anterior cingulate sulcal variability.Research square · 2024Article
- Dimensions of early life adversity and their associations with functional brain organisation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Structural Network Topology Reveals Higher Brain Resilience in Individuals with Preclinical Alzheimer's Disease.Brain connectivity · 2023Article
- Structural-functional connectivity bandwidth predicts processing speed in mild traumatic brain Injury: A multiplex network analysis.NeuroImage. Clinical · 2023Article
- Forecasting brain activity based on models of spatiotemporal brain dynamics: A comparison of graph neural network architectures.Network neuroscience (Cambridge, Mass.) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Several studies have suggested that functional connectivity (FC) is constrained by the underlying structural connectivity (SC) and mutually correlated. However, not many studies have focused on differences in the network organization of SC and FC, and on how these differences may inform us about their mutual interaction. To explore this issue, we adopt a multi-layer framework, with SC and FC, constructed using Magnetic Resonance Imaging (MRI) data from the Human Connectome Project, forming a two-layer multiplex network. In particular, we examine node strength assortativity within and between the SC and FC layer. We find that, in general, SC is organized assortatively, indicating brain regions are on average connected to other brain regions with similar node strengths. On the other hand, FC shows disassortative mixing. This discrepancy is apparent also among individual resting-state networks within SC and FC. In addition, these patterns show lateralization, with disassortative mixing within FC subnetworks mainly driven from the left hemisphere. We discuss our findings in the context of robustness to structural failure, and we suggest that discordant and lateralized patterns of associativity in SC and FC may provide clues to understand laterality of some neurological dysfunctions and recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.